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    zfp36l1a zinc finger protein 36, C3H type-like 1a [ Danio rerio (zebrafish) ]

    Gene ID: 561280, updated on 2-Nov-2024

    Summary

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    Official Symbol
    zfp36l1aprovided by ZNC
    Official Full Name
    zinc finger protein 36, C3H type-like 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9860
    See related
    Ensembl:ENSDARG00000016154 AllianceGenome:ZFIN:ZDB-GENE-030131-9860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb198; cb480; fk89d11; zfp36l1; zfp36l2; sb:cb198; sb:cb480; id:ibd1247; wu:fb80h11; wu:fb92f07; wu:fk89d11; zgc:153979
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity and metal ion binding activity. Predicted to be involved in 3'-UTR-mediated mRNA destabilization and positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. Is expressed in several structures, including anterior neural keel; immature eye; nervous system; splanchnocranium; and tail bud. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See zfp36l1a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (37790773..37795856, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (37843188..37848271, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 229B Neighboring gene uncharacterized LOC137488131 Neighboring gene uncharacterized LOC103909058 Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zfp36l1b protects angiogenesis through Notch1b/Dll4 and Vegfa regulation in zebrafish. Hu YX, et al. Atherosclerosis, 2020 Sep. PMID 32882641
    2. Efficient disruption of Zebrafish genes using a Gal4-containing gene trap. Balciuniene J, et al. BMC Genomics, 2013 Sep 14. PMID 24034702, Free PMC Article
    3. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
    4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA decay activator protein ZFP36L1a
    Names
    zinc finger protein 36, C3H type-like 1
    zinc finger protein 36, C3H type-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077153.2 → NP_001070621.2  mRNA decay activator protein ZFP36L1a

      Status: VALIDATED

      Source sequence(s)
      CR388389
      UniProtKB/TrEMBL
      A0A8M1NB74, F1RCP3
      Related
      ENSDARP00000025205.5, ENSDART00000025853.7
      Conserved Domains (2) summary
      pfam00642
      Location:145 → 170
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam04553
      Location:3 → 127
      Tis11B_N; Tis11B like protein, N terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      37790773..37795856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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