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    atp2a2b ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2b [ Danio rerio (zebrafish) ]

    Gene ID: 568265, updated on 2-Nov-2024

    Summary

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    Official Symbol
    atp2a2bprovided by ZNC
    Official Full Name
    ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-867
    See related
    Ensembl:ENSDARG00000005122 AllianceGenome:ZFIN:ZDB-GENE-030131-867
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    SERCA2; fb51e04; fb80c02; zK83D9.6; wu:fb51e04; wu:fb80c02; si:dkey-83d9.6
    Summary
    Predicted to enable P-type calcium transporter activity. Acts upstream of or within determination of heart left/right asymmetry. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in axis; myotome; pectoral fin; and pectoral fin musculature. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See atp2a2b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (17051047..17108479)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (17014235..17071388)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex, subunit 3 Neighboring gene ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast) Neighboring gene BCR activator of RhoGEF and GTPase Neighboring gene uncharacterized LOC137488793 Neighboring gene uncharacterized LOC137488792 Neighboring gene growth factor independent 1B transcription repressor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pathway-specific protein domains are predictive for human diseases. Shim JE, et al. PLoS Comput Biol, 2019 May. PMID 31075101, Free PMC Article
    2. Exposure to water-accommodated fractions of two different crude oils alters morphology, cardiac function and swim bladder development in early-life stages of zebrafish. Li X, et al. Chemosphere, 2019 Nov. PMID 31272002
    3. Influences of domoic Acid exposure on cardiac development and the expression of cardiovascular relative genes in zebrafish (Daniorerio) embryos. Hong Z, et al. J Biochem Mol Toxicol, 2015 Jun. PMID 25691335
    4. Transgenerational inheritance of heart disorders caused by paternal bisphenol A exposure. Lombó M, et al. Environ Pollut, 2015 Nov. PMID 26322593
    5. Characterization of the POU5F1 Homologue in Nile Tilapia: From Expression Pattern to Biological Activity. Xiaohuan H, et al. Stem Cells Dev, 2016 Sep 15. PMID 27473876

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cardiac muscle contraction by calcium ion signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sarcoplasmic/endoplasmic reticulum calcium ATPase 2b
    Names
    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2b
    sarcoplasmic/endoplasmic-reticulum Ca(2+) pump gene 2
    NP_001025448.1
    XP_005161253.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030277.1 → NP_001025448.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2b

      Status: PROVISIONAL

      Source sequence(s)
      AL844518
      UniProtKB/TrEMBL
      A0A8M1N7U6, Q6ZM60
      Related
      ENSDARP00000047200.5, ENSDART00000047201.6
      Conserved Domains (6) summary
      TIGR01116
      Location:47 → 981
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:87 → 334
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:776 → 978
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 66
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:596 → 704
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:413 → 520
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      17051047..17108479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161196.5 → XP_005161253.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2b isoform X1

      UniProtKB/TrEMBL
      A0A0R4IQS8, A0A8M2B848
      Related
      ENSDARP00000136537.1, ENSDART00000161650.3
      Conserved Domains (6) summary
      TIGR01116
      Location:53 → 987
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:93 → 340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:782 → 984
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 72
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:602 → 710
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419 → 526
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein Strain
    Heading Accession and Version

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