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    fhl3b four and a half LIM domains 3b [ Danio rerio (zebrafish) ]

    Gene ID: 555053, updated on 2-Nov-2024

    Summary

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    Official Symbol
    fhl3bprovided by ZNC
    Official Full Name
    four and a half LIM domains 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8356
    See related
    Ensembl:ENSDARG00000104315 AllianceGenome:ZFIN:ZDB-GENE-030131-8356
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb09g09; zgc:63514; wu:fb09g09
    Summary
    Predicted to enable actin binding activity and transcription coregulator activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be active in Z disc; nucleus; and stress fiber. Orthologous to human FHL3 (four and a half LIM domains 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See fhl3b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (4089494..4118394, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (4158668..4187555, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene zgc:173581 Neighboring gene bloodthirsty-related gene family, member 26 Neighboring gene si:dkey-218f9.10 Neighboring gene Ras-related GTP binding Cb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles. Dennhag N, et al. Nat Commun, 2024 Mar 2. PMID 38431640, Free PMC Article
    2. Role of microRNAs and their downstream target transcription factors in zebrafish thrombopoiesis. Al Qaryoute A, et al. Sci Rep, 2023 Sep 26. PMID 37752184, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63514

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    four and a half LIM domains protein 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099978.1 → NP_001093448.1  four and a half LIM domains protein 3b

      See identical proteins and their annotated locations for NP_001093448.1

      Status: PROVISIONAL

      Source sequence(s)
      CR853286
      UniProtKB/TrEMBL
      A0A8M1NDX6, A5WUZ4
      Related
      ENSDARP00000131910.1, ENSDART00000169758.2
      Conserved Domains (5) summary
      cd09346
      Location:162 → 213
      LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
      cd09423
      Location:36 → 94
      LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cd09427
      Location:98 → 155
      LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cd09434
      Location:221 → 276
      LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      4089494..4118394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173745.5 → XP_005173802.1  four and a half LIM domains protein 3b isoform X1

      See identical proteins and their annotated locations for XP_005173802.1

      UniProtKB/TrEMBL
      A0A8M1NDX6, A5WUZ4
      Conserved Domains (5) summary
      cd09346
      Location:162 → 213
      LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
      cd09423
      Location:36 → 94
      LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cd09427
      Location:98 → 155
      LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cd09434
      Location:221 → 276
      LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version

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