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    cpa4 carboxypeptidase A4 [ Danio rerio (zebrafish) ]

    Gene ID: 431764, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cpa4provided by ZNC
    Official Full Name
    carboxypeptidase A4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040704-61
    See related
    Ensembl:ENSDARG00000043722 AllianceGenome:ZFIN:ZDB-GENE-040704-61
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:91794; wu:fb66g10
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in pancreas and somite. Orthologous to several human genes including CPA2 (carboxypeptidase A2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See cpa4 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (16582172..16589461, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (16485772..16493061, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene suppressor APC domain-containing protein 1-like Neighboring gene structural maintenance of chromosomes 1B Neighboring gene carboxypeptidase A2 (pancreatic) Neighboring gene ATPase H+ transporting V1 subunit E1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases. Akula S, et al. Dev Comp Immunol, 2022 Feb. PMID 34619175
    2. Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding. Lyons PJ, et al. PLoS One, 2010 Sep 24. PMID 20885977, Free PMC Article
    3. Knockout of zebrafish colony-stimulating factor 1 receptor by CRISPR/Cas9 affects metabolism and locomotion capacity. Meng H, et al. Biochem Biophys Res Commun, 2021 Apr 30. PMID 33725575
    4. Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules. Lopes MW, et al. PLoS One, 2016. PMID 27050163, Free PMC Article
    5. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Zhai G, et al. J Genet Genomics, 2017 Jun 20. PMID 28642062

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase A4
    NP_001002217.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002217.1 → NP_001002217.1  carboxypeptidase A4 precursor

      See identical proteins and their annotated locations for NP_001002217.1

      Status: PROVISIONAL

      Source sequence(s)
      BC074071
      UniProtKB/TrEMBL
      Q6GMH9
      Related
      ENSDARP00000064203.3, ENSDART00000064204.4
      Conserved Domains (2) summary
      cd03870
      Location:115 → 415
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:27 → 97
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      16582172..16589461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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