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    prickle1b prickle homolog 1b [ Danio rerio (zebrafish) ]

    Gene ID: 556148, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prickle1bprovided by ZNC
    Official Full Name
    prickle homolog 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2152
    See related
    Ensembl:ENSDARG00000045694 AllianceGenome:ZFIN:ZDB-GENE-030131-2152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb98c11; wu:fb98c11; si:ch211-155a11.1
    Summary
    Predicted to enable zinc ion binding activity. Acts upstream of with a positive effect on motor neuron migration. Acts upstream of or within nervous system development and neural crest cell migration. Predicted to be located in membrane. Is expressed in several structures, including mesoderm; myotome; nervous system; neuroepithelial cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prickle1b in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (13963499..13995800, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (13964650..13996960, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type and RNA binding motif 1 Neighboring gene periphilin 1 Neighboring gene pseudouridylate synthase PUS7L-like Neighboring gene uncharacterized LOC137491529 Neighboring gene pseudouridylate synthase PUS7L-like Neighboring gene uncharacterized LOC137491528

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration. Mapp OM, et al. Dev Dyn, 2010 Jun. PMID 20503357, Free PMC Article
    2. Prickle1 is required for EMT and migration of zebrafish cranial neural crest. Ahsan K, et al. Dev Biol, 2019 Apr 1. PMID 30721665, Free PMC Article
    3. Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance. Sun SD, et al. BMC Neurosci, 2016 Dec 12. PMID 27955617, Free PMC Article
    4. Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity. Mapp OM, et al. Development, 2011 May. PMID 21521740, Free PMC Article
    5. PCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional Migration. Davey CF, et al. PLoS Genet, 2016 Mar. PMID 26990447, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. uncovered roles for pk1a and pk1b in the epithelial-to-mesenchymal transition (EMT) of pre-migratory NCCs that precedes their collective migration to the periphery.
      Title: Prickle1 is required for EMT and migration of zebrafish cranial neural crest.
    2. Farnesylation of a tagged Pk1b is required for its nuclear localization and facial branchiomotor neuron migration.
      Title: Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity.
    3. our data suggest that Pk1b function may be required to integrate the multiple migratory cues received by the neurons into polarization instructions for proper posterior movement.
      Title: Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration.
    4. show that anterior hindbrain (r2/r3) motor neuron migration appears to be independent of vangl2 and pk1b functions, and suggest that multiple mechanisms regulate motor neuron migration along the anterior-posterior axis of the zebrafish hindbrain
      Title: Multiple mechanisms mediate motor neuron migration in the zebrafish hindbrain.
    5. Hoxb1a target Prickle1b functions cell-autonomously to control facial neuron migration, a single aspect of r4 identity.
      Title: Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within facial nucleus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hindbrain tangential cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within motor neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect motor neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prickle-like protein 1b
    Names
    pk1b
    prickle homolog 1 b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030098.2 → NP_001025269.1  prickle-like protein 1b

      Status: PROVISIONAL

      Source sequence(s)
      AI588252, AL929504, EB928759
      UniProtKB/TrEMBL
      A0A8M1N760, F2Z4V3
      Related
      ENSDARP00000067176.4, ENSDART00000067177.6
      Conserved Domains (4) summary
      cd09415
      Location:146 → 204
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:209 → 264
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:269 → 327
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:43 → 139
      PET_Prickle; The PET domain of Prickle

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      13963499..13995800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164634.5 → XP_005164691.1  prickle-like protein 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BBR2, Q5SP54
      Related
      ENSDARP00000118988.1, ENSDART00000147955.3
      Conserved Domains (4) summary
      cd09415
      Location:137 → 195
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:200 → 255
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:260 → 318
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:34 → 130
      PET_Prickle; The PET domain of Prickle
    Nucleotide Protein Strain
    Heading Accession and Version

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