U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    polr3b polymerase (RNA) III (DNA directed) polypeptide B [ Danio rerio (zebrafish) ]

    Gene ID: 562329, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    polr3bprovided by ZNC
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2887
    See related
    Ensembl:ENSDARG00000062915 AllianceGenome:ZFIN:ZDB-GENE-030131-2887
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc20h06; si:dkey-103i16.3
    Summary
    Predicted to enable several functions, including DNA-directed 5'-3' RNA polymerase activity; metal ion binding activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase III activity. Acts upstream of or within digestive system development; regulation of cerebellar neuron development; and tRNA transcription. Predicted to be part of RNA polymerase III complex. Is expressed in intestine; liver; nervous system; retina; and telencephalon. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and hypomyelinating leukodystrophy 8. Orthologous to human POLR3B (RNA polymerase III subunit B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See polr3b in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (15381750..15420264, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (15413238..15451784, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene RIC8 guanine nucleotide exchange factor B Neighboring gene regulatory factor X, 4 Neighboring gene uncharacterized LOC137488263 Neighboring gene uncharacterized LOC110438087

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Intestinal growth and differentiation in zebrafish. Wallace KN, et al. Mech Dev, 2005 Feb. PMID 15652704
    2. Identification of POLR3B biallelic mutations-associated hypomyelinating leukodystrophy-8 in two siblings. Yang F, et al. Clin Genet, 2023 May. PMID 36650939
    3. Mutations affecting development of zebrafish digestive organs. Pack M, et al. Development, 1996 Dec. PMID 9007252
    4. Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. Yee NS, et al. PLoS Biol, 2007 Nov. PMID 18044988, Free PMC Article
    5. A genetic screen for mutations affecting embryogenesis in zebrafish. Driever W, et al. Development, 1996 Dec. PMID 9007227

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cerebellar neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA-directed RNA polymerase III subunit RPC2
    Names
    slim jim
    slj
    XP_021323450.1
    XP_690811.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      15381750..15420264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467775.2 → XP_021323450.1  DNA-directed RNA polymerase III subunit RPC2

      UniProtKB/TrEMBL
      A0A8N7T7P2, F1QQA2
      Related
      ENSDARP00000085899.5, ENSDART00000091466.7
      Conserved Domains (3) summary
      cd00653
      Location:37 → 1124
      RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
      pfam04566
      Location:536 → 597
      RNA_pol_Rpb2_4; RNA polymerase Rpb2, domain 4
      pfam04567
      Location:618 → 658
      RNA_pol_Rpb2_5; RNA polymerase Rpb2, domain 5

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395015.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      220763..259125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_685719.8 → XP_690811.2  DNA-directed RNA polymerase III subunit RPC2

      UniProtKB/TrEMBL
      A0A8N7T7P2, F1QQA2
      Conserved Domains (3) summary
      cd00653
      Location:37 → 1124
      RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
      pfam04566
      Location:536 → 597
      RNA_pol_Rpb2_4; RNA polymerase Rpb2, domain 4
      pfam04567
      Location:618 → 658
      RNA_pol_Rpb2_5; RNA polymerase Rpb2, domain 5
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools