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    farp2 FERM, RhoGEF and pleckstrin domain protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 567490, updated on 14-Nov-2024

    Summary

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    Official Symbol
    farp2provided by ZNC
    Official Full Name
    FERM, RhoGEF and pleckstrin domain protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2993
    See related
    Ensembl:ENSDARG00000016429 AllianceGenome:ZFIN:ZDB-GENE-030131-2993
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Runx2a; wu:fc23d05; wu:fp25d09
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoskeleton. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See farp2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (26948128..27038629)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (26957534..27048070)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene high density lipoprotein binding protein a Neighboring gene ephexin-1 Neighboring gene serine/threonine kinase 25a Neighboring gene BCL2 family apoptosis regulator BOK a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structural analyses of FERM domain-mediated membrane localization of FARP1. Kuo YC, et al. Sci Rep, 2018 Jul 11. PMID 29992992, Free PMC Article
    2. Identification and characterisation of two runx2 homologues in zebrafish with different expression patterns. van der Meulen T, et al. Biochim Biophys Acta, 2005 Jun 30. PMID 15894389
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM, RhoGEF and pleckstrin domain-containing protein 2; FERM, ARHGEF and pleckstrin domain-containing protein 2
    Names
    Runx2a splice form 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      26948128..27038629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302421.3 → XP_009300696.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ATD1
      Conserved Domains (9) summary
      smart00295
      Location:53 → 241
      B41; Band 4.1 homologues
      cd01220
      Location:747 → 861
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:228 → 348
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:933 → 1030
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam00169
      Location:938 → 1031
      PH; PH domain
      pfam00373
      Location:138 → 241
      FERM_M; FERM central domain
      pfam00621
      Location:537 → 720
      RhoGEF; RhoGEF domain
      pfam08736
      Location:341 → 382
      FA; FERM adjacent (FA)
      pfam09379
      Location:55 → 118
      FERM_N; FERM N-terminal domain

    2. XM_021477117.2 → XP_021332792.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PMS8
      Conserved Domains (6) summary
      smart00295
      Location:53 → 241
      B41; Band 4.1 homologues
      cd00160
      Location:535 → 722
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:747 → 861
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:228 → 348
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:925 → 1022
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:341 → 382
      FA; FERM adjacent (FA)

    3. XM_068221972.1 → XP_068078073.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X2

      Related
      ENSDARP00000129410.1, ENSDART00000153595.3

    4. XM_021477118.2 → XP_021332793.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q0H0
      Conserved Domains (6) summary
      smart00295
      Location:53 → 241
      B41; Band 4.1 homologues
      cd00160
      Location:520 → 707
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:732 → 846
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:228 → 348
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:918 → 1015
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:341 → 382
      FA; FERM adjacent (FA)

    5. XM_068221973.1 → XP_068078074.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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