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    dab2 DAB adaptor protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 404040, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dab2provided by ZNC
    Official Full Name
    DAB adaptor protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040303-1
    See related
    Ensembl:ENSDARG00000031761 AllianceGenome:ZFIN:ZDB-GENE-040303-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb778; zgc:77136
    Summary
    Predicted to enable cargo receptor activity and clathrin adaptor activity. Acts upstream of or within several processes, including Notch signaling pathway; regulation of cardiac muscle cell differentiation; and regulation of signal transduction. Predicted to be active in clathrin-coated pit; cytoplasm; and intracellular membrane-bounded organelle. Is expressed in several structures, including intermediate cell mass of mesoderm; pleuroperitoneal region; vascular cord; vasculature; and ventral mesoderm. Orthologous to human DAB2 (DAB adaptor protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See dab2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (32323775..32338873, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (31723622..31738851, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 1.1, skeletal muscle Neighboring gene heat shock protein, alpha-crystallin-related, b15 Neighboring gene complement component 9 Neighboring gene growth arrest-specific 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. YULINK regulates vascular formation in zebrafish and HUVECs. Lin HH, et al. Biol Res, 2023 Feb 27. PMID 36843032, Free PMC Article
    2. Characterisation and differential expression during development of a duplicate Disabled-1 (Dab1) gene from zebrafish. Herrero-Turrión MJ, et al. Comp Biochem Physiol B Biochem Mol Biol, 2010 Mar. PMID 19931637
    3. Development and origins of zebrafish ocular vasculature. Kaufman R, et al. BMC Dev Biol, 2015 Mar 27. PMID 25888280, Free PMC Article
    4. Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk. Grimm L, et al. Elife, 2019 Apr 30. PMID 31038457, Free PMC Article
    5. Posterior-anterior gradient of zebrafish hes6 expression in the presomitic mesoderm is established by the combinatorial functions of the downstream enhancer and 3'UTR. Kawamura A, et al. Dev Biol, 2016 Jan 15. PMID 26596999

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. inhibition of Dab2 decreases phosphorylation of SMAD-1, 5, and 8
      Title: Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.
    2. Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing PP1 from binding Axin
      Title: Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cargo receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of epithelial to mesenchymal transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vasculature development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disabled homolog 2
    Names
    Dab, mitogen-responsive phosphoprotein, homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327871.1 → NP_001314800.1  disabled homolog 2 isoform a

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      BX510649
      UniProtKB/TrEMBL
      A0A8M1P9G4, B8A566
      Related
      ENSDARP00000047669.7, ENSDART00000047670.8
      Conserved Domains (1) summary
      cd01215
      Location:47 → 196
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

    2. NM_001327872.1 → NP_001314801.1  disabled homolog 2 isoform b

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      BX510649
      UniProtKB/TrEMBL
      A0A8M1P8E6, F6NGQ6
      Related
      ENSDARP00000028118.8, ENSDART00000017956.10
      Conserved Domains (2) summary
      cd01215
      Location:47 → 196
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
      pfam09606
      Location:303 → 399
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    3. NM_205757.3 → NP_991320.2  disabled homolog 2 isoform b

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      BX510649
      UniProtKB/TrEMBL
      A0A8M1P8E6, F6NGQ6
      Related
      ENSDARP00000113909.1, ENSDART00000139732.3
      Conserved Domains (2) summary
      cd01215
      Location:47 → 196
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
      pfam09606
      Location:303 → 399
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      32323775..32338873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171819.5 → XP_005171876.1  disabled homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_005171876.1

      UniProtKB/TrEMBL
      A0A8M1P9G4, B8A566
      Conserved Domains (1) summary
      cd01215
      Location:47 → 196
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

    2. XM_021476051.2 → XP_021331726.1  disabled homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M1P8E6, F6NGQ6
      Conserved Domains (2) summary
      cd01215
      Location:47 → 196
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
      pfam09606
      Location:303 → 399
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    Nucleotide Protein
    Heading Accession and Version

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