uqcc2 ubiquinol-cytochrome c reductase complex assembly factor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uqcc2provided by ZNC
Official Full Name: ubiquinol-cytochrome c reductase complex assembly factor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1726
See related: Ensembl:ENSDARG00000011272 AllianceGenome:ZFIN:ZDB-GENE-040426-1726
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mnf1; zgc:73238
Summary: Predicted to be involved in several processes, including mitochondrial respiratory chain complex III assembly; positive regulation of mitochondrial translation; and regulation of insulin secretion. Predicted to be located in mitochondrial inner membrane; mitochondrial intermembrane space; and mitochondrial nucleoid. Predicted to be active in mitochondrial matrix. Is expressed in intestinal bulb; intestinal bulb primordium; liver; and pectoral fin musculature. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 7. Orthologous to human UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (40573267..40577109)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (40575731..40579573)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in mitochondrial respiratory chain complex III assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial respiratory chain complex III assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respiratory chain complex III assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of oxidative phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of skeletal muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquinol-cytochrome-c reductase complex assembly factor 2

Names: mitochondrial nucleoid factor 1; mitochondrial protein M19

NP_957052.1

EC 2.7.4.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.