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    IFI35 interferon induced protein 35 [ Homo sapiens (human) ]

    Gene ID: 3430, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IFI35provided by HGNC
    Official Full Name
    interferon induced protein 35provided by HGNC
    Primary source
    HGNC:HGNC:5399
    See related
    Ensembl:ENSG00000068079 MIM:600735; AllianceGenome:HGNC:5399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IFP35
    Summary
    Enables identical protein binding activity. Involved in several processes, including macrophage activation involved in immune response; negative regulation of non-canonical NF-kappaB signal transduction; and positive regulation of defense response. Located in several cellular components, including cytosol; extracellular space; and nuclear lumen. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 18.2), appendix (RPKM 14.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IFI35 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43006784..43014456)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43864072..43871742)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41158801..41166473)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8549 Neighboring gene RUN domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41142673-41143174 Neighboring gene uncharacterized LOC124904006 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:41149993-41151192 Neighboring gene ribosomal protein L27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12233 Neighboring gene vesicle amine transport 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8550 Neighboring gene Rho family GTPase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1. Brown MA, et al. Proc Natl Acad Sci U S A, 1995 May 9. PMID 7753812, Free PMC Article
    2. IFP35 Is a Relevant Factor in Innate Immunity, Multiple Sclerosis, and Other Chronic Inflammatory Diseases: A Review. De Masi R, et al. Biology (Basel), 2021 Dec 14. PMID 34943240, Free PMC Article
    3. IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus. Tan J, et al. J Virol, 2008 May. PMID 18305040, Free PMC Article
    4. IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis. De Masi R, et al. Life Sci, 2020 Oct 15. PMID 32781067
    5. The role of IFI35 in lupus nephritis and related mechanisms. Zhang L, et al. Mod Rheumatol, 2017 Nov. PMID 28064541

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IFP35 family proteins promote neuroinflammation and multiple sclerosis.
      Title: IFP35 family proteins promote neuroinflammation and multiple sclerosis.
    2. IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis.
      Title: IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis.
    3. inhibits both endothelial cell proliferation and migration by inhibiting the NF-kappaB/p65 pathway; functionally interacts with Nmi through its NID1 domain
      Title: Interferon-induced protein 35 inhibits endothelial cell proliferation, migration and re-endothelialization of injured arteries by inhibiting the nuclear factor-kappa B pathway.
    4. IFI35 enhances proliferation of mesangial cells and is regulated by MBD2 in lupus nephritis.
      Title: The role of IFI35 in lupus nephritis and related mechanisms.
    5. Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-kappaB pathways.
      Title: NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.
    6. Study found that TLR3 signaling induces the expression of IFI35, and IFI35 negatively regulates IFN-beta-P-STAT1-RIG-I-CXCL10/CCL5 axis in U373MG cells. This suggests that IFI35 expressed in astrocytes may play an important role in regulating the innate immune system in astrocytoma cells.
      Title: Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-β-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.
    7. Activation of TLR3 by poly IC induces the IFI35 expression in Mesangial Cells. Regional expression of IFI35 and its dysregulation may be involved in the pathogenesis of glomerular inflammation in CKD.
      Title: Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.
    8. Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response
      Title: Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response.
    9. Knockdown of IFP35 expression abolished pEGFP-N1-2C and pEGFP-N1-Nmi-induced activation of type I interferon promoters.
      Title: A critical role of interferon-induced protein IFP35 in the type I interferon response in cells induced by foot-and-mouth disease virus (FMDV) protein 2C.
    10. IFI35 negatively regulates RIG-I antiviral signaling and supports vesicular stomatitis virus replication.
      Title: Interferon-inducible protein IFI35 negatively regulates RIG-I antiviral signaling and supports vesicular stomatitis virus replication.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of interferon-inducible protein 35 (IFI35) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFI35, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of IFI35 in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21753

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon-induced 35 kDa protein
    Names
    IFP 35
    ifi-35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330230.2 → NP_001317159.1  interferon-induced 35 kDa protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA827287, AC055866
      Consensus CDS
      CCDS82134.1
      UniProtKB/Swiss-Prot
      C9JGX1, P80217, Q92984, Q99537, Q9BV98
      Related
      ENSP00000394579.3, ENST00000415816.7

    2. NM_005533.5 → NP_005524.2  interferon-induced 35 kDa protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA740882, AA832092, BC001356, BU571030
      Consensus CDS
      CCDS11450.1
      UniProtKB/Swiss-Prot
      P80217
      Related
      ENSP00000395590.2, ENST00000438323.2
      Conserved Domains (2) summary
      pfam07292
      Location:183 → 268
      NID; Nmi/IFP 35 domain (NID)
      pfam07334
      Location:9 → 80
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43006784..43014456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024584.2 → XP_016880073.1  interferon-induced 35 kDa protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      43864072..43871742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315946.1 → XP_054171921.1  interferon-induced 35 kDa protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80217.5 GenPept UniProtKB/Swiss-Prot:P80217

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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