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    Immp2l IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 93757, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Immp2lprovided by MGI
    Official Full Name
    IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:2135611
    See related
    Ensembl:ENSMUSG00000056899 AllianceGenome:MGI:2135611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IMP2; Tg(HLA-A/H2-D)2Enge
    Summary
    Enables peptidase activity. Acts upstream of or within several processes, including cerebellum vasculature development; ovulation; and protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Part of mitochondrial inner membrane peptidase complex. Orthologous to human IMMP2L (inner mitochondrial membrane peptidase subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 4.9), liver adult (RPKM 3.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Immp2l in Genome Data Viewer
    Location:
    12 B1; 12 18.69 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (41074060..42002371)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (41024061..41955588)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31972 Neighboring gene STARR-seq mESC enhancer starr_31975 Neighboring gene zinc finger protein 511 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31978 Neighboring gene STARR-seq mESC enhancer starr_31979 Neighboring gene STARR-seq mESC enhancer starr_31980 Neighboring gene heat shock protein 90, beta (Grp94), member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31981 Neighboring gene STARR-seq mESC enhancer starr_31982 Neighboring gene STARR-seq mESC enhancer starr_31983 Neighboring gene predicted gene 4274 Neighboring gene STARR-seq mESC enhancer starr_31984 Neighboring gene STARR-seq mESC enhancer starr_31985 Neighboring gene STARR-seq mESC enhancer starr_31987 Neighboring gene STARR-seq mESC enhancer starr_31989 Neighboring gene predicted gene, 51974 Neighboring gene predicted gene, 25497 Neighboring gene STARR-seq mESC enhancer starr_31990 Neighboring gene STARR-seq mESC enhancer starr_31991 Neighboring gene leucine rich repeat protein 3, neuronal Neighboring gene STARR-seq mESC enhancer starr_31992 Neighboring gene STARR-seq mESC enhancer starr_31994 Neighboring gene STARR-seq mESC enhancer starr_31995 Neighboring gene predicted gene, 40412 Neighboring gene STARR-seq mESC enhancer starr_31996 Neighboring gene STARR-seq mESC enhancer starr_31997 Neighboring gene STARR-seq mESC enhancer starr_31998 Neighboring gene predicted gene, 46348 Neighboring gene STARR-seq mESC enhancer starr_31999 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9b pseudogene Neighboring gene STARR-seq mESC enhancer starr_32000 Neighboring gene STARR-seq mESC enhancer starr_32002 Neighboring gene STARR-seq mESC enhancer starr_32003 Neighboring gene STARR-seq mESC enhancer starr_32004 Neighboring gene STARR-seq mESC enhancer starr_32005 Neighboring gene predicted gene, 33340

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Combined prophylactic and therapeutic cancer vaccine: enhancing CTL responses to HPV16 E2 using a chimeric VLP in HLA-A2 mice. Qian J, et al. Int J Cancer, 2006 Jun 15. PMID 16425257
    2. Oxidative stress is involved in age-dependent spermatogenic damage of Immp2l mutant mice. George SK, et al. Free Radic Biol Med, 2012 Jun 1-15. PMID 22569411, Free PMC Article
    3. Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response. Madsen CB, et al. PLoS One, 2012. PMID 23189185, Free PMC Article
    4. Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control. Hong M, et al. Cancer Res, 2011 Nov 15. PMID 21948969
    5. Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal. George SK, et al. Aging Cell, 2011 Aug. PMID 21332923, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase.
      Title: Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase.
    2. Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse.
      Title: Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse.
    3. Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder.
      Title: Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder.
    4. Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice.
      Title: Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice.
    5. Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage.
      Title: Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage.
    6. LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
      Title: LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
    7. [IMMP2L gene mutation activates mitochondrial apoptotic pathway to aggravate cerebral ischemic injury in mice].
      Title: [IMMP2L gene mutation activates mitochondrial apoptotic pathway to aggravate cerebral ischemic injury in mice].
    8. The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/beta-Catenin-Estrogen Pathway: Preventive Effect of Melatonin.
      Title: The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/β-Catenin-Estrogen Pathway: Preventive Effect of Melatonin.
    9. IMP2-deficient muscle exhibits reduced fatty acid oxidation, due to a reduced abundance of mRNA of peroxisome proliferator-activated receptor alpha (PPARalpha), an IMP2 client, and PPARalpha protein. IMP2-deficient muscle fibers treated with a mitochondrial uncoupler to increase electron flux, as occurs with exercise, exhibit reduced oxygen consumption from fatty acids, with higher oxygen consumption from glucose.
      Title: IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism.
    10. Data indicates that overexpression of IMP2 alters the regulatory capacity of many miRNAs and conclude that IMP2 competes with miRNAs for binding sites on thousands of transcripts. As a result, data implicates that overexpression of IMP2 has distinct effects to the regulatory capacity of miRNAs with yet unknown consequences for translational efficiency.
      Title: Transgenic expression of the RNA binding protein IMP2 stabilizes miRNA targets in murine microsteatosis.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (4) 
    • Transgenic (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptidase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within blood circulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebellum vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial respiratory chain complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ovulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein processing involved in protein targeting to mitochondrion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within respiratory electron transport chain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within superoxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    part_of mitochondrial inner membrane peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial inner membrane peptidase complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    mitochondrial inner membrane protease subunit 2
    Names
    AAD mice
    IMP2-like protein
    NP_444352.2
    XP_017170750.1
    XP_017170751.1
    XP_030102864.1
    XP_036013583.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053122.5 → NP_444352.2  mitochondrial inner membrane protease subunit 2

      See identical proteins and their annotated locations for NP_444352.2

      Status: VALIDATED

      Source sequence(s)
      AC123620, AC124826, AC153793, AC240395
      Consensus CDS
      CCDS83961.1
      UniProtKB/Swiss-Prot
      Q3TTI2, Q8BPT6, Q925F6
      Related
      ENSMUSP00000118779.2, ENSMUST00000132121.8
      Conserved Domains (2) summary
      cd06530
      Location:36 → 146
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
      TIGR02227
      Location:33 → 152
      sigpep_I_bact; signal peptidase I, bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      41074060..42002371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247004.2 → XP_030102864.1  mitochondrial inner membrane protease subunit 2 isoform X3

      Conserved Domains (1) summary
      cd06530
      Location:36 → 77
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

    2. XM_036157690.1 → XP_036013583.1  mitochondrial inner membrane protease subunit 2 isoform X4

      Conserved Domains (1) summary
      cd06530
      Location:36 → 77
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

    3. XM_017315261.3 → XP_017170750.1  mitochondrial inner membrane protease subunit 2 isoform X1

      Conserved Domains (1) summary
      TIGR02227
      Location:53 → 125
      sigpep_I_bact; signal peptidase I, bacterial type

    4. XM_017315262.2 → XP_017170751.1  mitochondrial inner membrane protease subunit 2 isoform X2

      Conserved Domains (1) summary
      TIGR02227
      Location:73 → 117
      sigpep_I_bact; signal peptidase I, bacterial type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BPT6.1 GenPept UniProtKB/Swiss-Prot:Q8BPT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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