PRKCE protein kinase C epsilon [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRKCEprovided by HGNC
Official Full Name: protein kinase C epsilonprovided by HGNC
Primary source: HGNC:HGNC:9401
See related: Ensembl:ENSG00000171132 MIM:176975; AllianceGenome:HGNC:9401
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PKCE; nPKC-epsilon
Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
Expression: Broad expression in brain (RPKM 4.7), lung (RPKM 2.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p21

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (45651279..46187990)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (45656327..46193193)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (45878814..46415129)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The binding of PKCepsilon and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain.
Title: The binding of PKCε and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain.
Cross talk of tumor protein D52 (TPD52) with KLF9, PKCepsilon, and MicroRNA 223 in ovarian cancer.
Title: Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer.
Effects of PKCepsilon knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo.
Title: Effects of PKCε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo.
Apolipoprotein E epsilon4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCepsilon mislocalization in cholinergic neuronal cells.
Title: Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells.
Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatocellular carcinoma.
Title: Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatocellular carcinoma.
Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Title: Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters.
Title: Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters.
PKCepsilon regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells.
Title: PKCε regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells.
A genetically-encoded crosslinker screen identifies SERBP1 as a PKCepsilon substrate influencing translation and cell division.
Title: A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division.
Role of PKCepsilon in the epithelial-mesenchymal transition induced by FGFR2 isoform switch.
Title: Role of PKCε in the epithelial-mesenchymal transition induced by FGFR2 isoform switch.

Submit: New GeneRIF Correction See all GeneRIFs (216)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of hematological and biochemical traits in a Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of lung function decline in adults with and without asthma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of suicide attempts in mood disorder patients. EBI GWAS Catalog EBI GWAS CatalogPubMed
Impact of ancestry and common genetic variants on QT interval in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
Seventy-five genetic loci influencing the human red blood cell. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896	PubMed
	env	Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection	PubMed
	env	c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
	env	Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax	PubMed
	env	HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels	PubMed
	env	A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C	PubMed
	env	IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A	PubMed
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate	PubMed
	env	A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC	PubMed
Nef	nef	HIV-1 Nef involves PRKCE in the induction of IL6 and CXCL8 (IL8) expression	PubMed
	nef	HIV-1 Nef downregulates the expression of PKC epsilon in human astrocytoma cells	PubMed
Tat	tat	Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT	PubMed
	tat	Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth	PubMed
	tat	Protein kinase C phosphorylates HIV-1 Tat on serine residue 46	PubMed
	tat	HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1	PubMed
matrix	gag	Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation	PubMed
retropepsin	gag-pol	Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease	PubMed
reverse transcriptase	gag-pol	HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-63514 (e-PCR)
- UniSTS:44032

G20720 (e-PCR)
- UniSTS:11271

A006D15 (e-PCR)
- UniSTS:11272

RH98368 (e-PCR)
- UniSTS:89368

D2S391 (e-PCR), detects polymorphism
- UniSTS:19757

SHGC-84453 (e-PCR)
- UniSTS:104749

D2S2182 (e-PCR), detects polymorphism
- UniSTS:49969

D2S1489 (e-PCR)
- UniSTS:150329

RH18396 (e-PCR)
- UniSTS:63292

RH91418 (e-PCR)
- UniSTS:85822

RH91582 (e-PCR)
- UniSTS:84307

D2S391 (e-PCR), detects polymorphism
- UniSTS:56147

WI-10633 (e-PCR)
- UniSTS:73305

D2S2240 (e-PCR), detects polymorphism
- UniSTS:49503

RH48314 (e-PCR)
- UniSTS:39038

D2S1953E (e-PCR)
- UniSTS:153727

RH118474 (e-PCR)
- UniSTS:137869

RH68597 (e-PCR)
- UniSTS:61072

WI-19686 (e-PCR)
- UniSTS:34193

RH119807 (e-PCR)
- UniSTS:133282

SHGC-81643 (e-PCR)
- UniSTS:103854

SHGC-107519 (e-PCR)
- UniSTS:170431

RH16512 (e-PCR)
- UniSTS:81867

SHGC-34686 (e-PCR)
- UniSTS:81868

D2S2378 (e-PCR), detects polymorphism
- UniSTS:48849

G63864 (e-PCR)
- UniSTS:139476

SHGC-148352 (e-PCR)
- UniSTS:176344

D2S1717E (e-PCR)
- UniSTS:150746

RH92278 (e-PCR)
- UniSTS:92388

WI-10606 (e-PCR)
- UniSTS:57839

WI-13380 (e-PCR)
- UniSTS:82678

G60078 (e-PCR)
- UniSTS:137208

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	TAS Traceable Author Statement more info
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ethanol binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis	TAS Traceable Author Statement more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in TRAM-dependent toll-like receptor 4 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to prostaglandin E stimulus	IEA Inferred from Electronic Annotation more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipopolysaccharide-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotory exploration behavior	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in mucus secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of sodium ion transmembrane transport	TAS Traceable Author Statement more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular glucuronidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mucus secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	TAS Traceable Author Statement more info	PubMed
acts_upstream_of positive regulation of superoxide anion generation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in response to morphine	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of toxin catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament cytoskeleton	IDA Inferred from Direct Assay more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein kinase C epsilon type

NP_005391.1

EC 2.7.11.13

XP_005264485.1

EC 2.7.11.13

XP_005264488.1

EC 2.7.11.13

XP_006712113.1

EC 2.7.11.13

XP_011531273.1

EC 2.7.11.13

XP_011531277.1

EC 2.7.11.13

XP_011531280.1

EC 2.7.11.13

XP_011531282.1

EC 2.7.11.13

XP_011531283.1

EC 2.7.11.13

XP_011531284.1

EC 2.7.11.13

XP_011531285.1

EC 2.7.11.13

XP_016859977.1

EC 2.7.11.13

XP_016859979.1

EC 2.7.11.13

XP_016859981.1

EC 2.7.11.13

XP_047301050.1

EC 2.7.11.13

XP_047301051.1

EC 2.7.11.13

XP_047301052.1

EC 2.7.11.13

XP_047301053.1

EC 2.7.11.13

XP_047301054.1

EC 2.7.11.13

XP_047301055.1

EC 2.7.11.13

XP_047301056.1

EC 2.7.11.13

XP_054198947.1

EC 2.7.11.13

XP_054198948.1

EC 2.7.11.13

XP_054198949.1

EC 2.7.11.13

XP_054198950.1

EC 2.7.11.13

XP_054198951.1

EC 2.7.11.13

XP_054198952.1

EC 2.7.11.13

XP_054198953.1

EC 2.7.11.13

XP_054198954.1

EC 2.7.11.13

XP_054198955.1

EC 2.7.11.13

XP_054198956.1

EC 2.7.11.13

XP_054198957.1

EC 2.7.11.13

XP_054198958.1

EC 2.7.11.13

XP_054198959.1

EC 2.7.11.13

XP_054198960.1

EC 2.7.11.13

XP_054198961.1

EC 2.7.11.13

XP_054198962.1

EC 2.7.11.13

XP_054198963.1

EC 2.7.11.13

XP_054198964.1

EC 2.7.11.13

XP_054198965.1

EC 2.7.11.13

XP_054198966.1

EC 2.7.11.13

XP_054198967.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005400.3 → NP_005391.1 protein kinase C epsilon type

See identical proteins and their annotated locations for NP_005391.1

Status: REVIEWED

Source sequence(s)

AL832345, BC054052, CA424727, U51244, X65293

Consensus CDS

CCDS1824.1

UniProtKB/Swiss-Prot

B0LPH7, Q02156, Q32MQ3, Q53SL4, Q53SM5, Q9UE81

UniProtKB/TrEMBL

B2R9M7, L7RTI5

Related

ENSP00000306124.3, ENST00000306156.8

Conserved Domains (4) summary

cd04014
Location:3 → 135

C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon

cd05591
Location:412 → 732

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

cd20835
Location:161 → 224

C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

cd20838
Location:241 → 295

C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

45651279..46187990

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005264428.2 → XP_005264485.1 protein kinase C epsilon type isoform X1

See identical proteins and their annotated locations for XP_005264485.1

UniProtKB/Swiss-Prot

B0LPH7, Q02156, Q32MQ3, Q53SL4, Q53SM5, Q9UE81

UniProtKB/TrEMBL

B2R9M7, L7RTI5

Conserved Domains (4) summary

cd04014
Location:3 → 135

C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon

cd05591
Location:412 → 732

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

cd20835
Location:161 → 224

C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

cd20838
Location:241 → 295

C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
XM_047445100.1 → XP_047301056.1 protein kinase C epsilon type isoform X10
XM_011532980.4 → XP_011531282.1 protein kinase C epsilon type isoform X4

See identical proteins and their annotated locations for XP_011531282.1

Conserved Domains (2) summary

cd05591
Location:262 → 582

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

pfam00130
Location:93 → 143

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_017004492.3 → XP_016859981.1 protein kinase C epsilon type isoform X7
XM_005264431.5 → XP_005264488.1 protein kinase C epsilon type isoform X6

Conserved Domains (3) summary

cd04014
Location:3 → 135

C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon

pfam00130
Location:243 → 295

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:412 → 479

PKc_like; Protein Kinases, catalytic domain
XM_047445094.1 → XP_047301050.1 protein kinase C epsilon type isoform X2
XM_011532971.4 → XP_011531273.1 protein kinase C epsilon type isoform X2

See identical proteins and their annotated locations for XP_011531273.1

UniProtKB/TrEMBL

B2R9M7

Conserved Domains (3) summary

smart00220
Location:312 → 572

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05591
Location:316 → 636

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

pfam00130
Location:147 → 199

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_017004490.3 → XP_016859979.1 protein kinase C epsilon type isoform X4

Conserved Domains (2) summary

cd05591
Location:262 → 582

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

pfam00130
Location:93 → 143

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_047445096.1 → XP_047301052.1 protein kinase C epsilon type isoform X2
XM_047445095.1 → XP_047301051.1 protein kinase C epsilon type isoform X2
XM_011532975.4 → XP_011531277.1 protein kinase C epsilon type isoform X2

See identical proteins and their annotated locations for XP_011531277.1

UniProtKB/TrEMBL

B2R9M7

Conserved Domains (3) summary

smart00220
Location:312 → 572

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05591
Location:316 → 636

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

pfam00130
Location:147 → 199

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_047445098.1 → XP_047301054.1 protein kinase C epsilon type isoform X2
XM_047445097.1 → XP_047301053.1 protein kinase C epsilon type isoform X2
XM_017004488.3 → XP_016859977.1 protein kinase C epsilon type isoform X3

UniProtKB/TrEMBL

B2R9M7

Conserved Domains (3) summary

smart00220
Location:294 → 554

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05591
Location:298 → 618

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

pfam00130
Location:129 → 181

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_011532978.3 → XP_011531280.1 protein kinase C epsilon type isoform X3

See identical proteins and their annotated locations for XP_011531280.1

UniProtKB/TrEMBL

B2R9M7

Conserved Domains (3) summary

smart00220
Location:294 → 554

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05591
Location:298 → 618

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

pfam00130
Location:129 → 181

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_047445099.1 → XP_047301055.1 protein kinase C epsilon type isoform X3
XM_011532981.4 → XP_011531283.1 protein kinase C epsilon type isoform X4

See identical proteins and their annotated locations for XP_011531283.1

Conserved Domains (2) summary

cd05591
Location:262 → 582

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

pfam00130
Location:93 → 143

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_011532982.3 → XP_011531284.1 protein kinase C epsilon type isoform X5

Conserved Domains (3) summary

smart00220
Location:168 → 428

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05591
Location:172 → 492

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

pfam00130
Location:3 → 55

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_006712050.4 → XP_006712113.1 protein kinase C epsilon type isoform X8

Conserved Domains (2) summary

smart00220
Location:131 → 391

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05591
Location:135 → 455

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
XM_011532983.3 → XP_011531285.1 protein kinase C epsilon type isoform X9

Conserved Domains (2) summary

smart00220
Location:107 → 367

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05591
Location:111 → 431

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon