U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    usp32 ubiquitin specific peptidase 32 [ Danio rerio (zebrafish) ]

    Gene ID: 557981, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    usp32provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 32provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100210-5
    See related
    Ensembl:ENSDARG00000061895 AllianceGenome:ZFIN:ZDB-GENE-100210-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fe14d02
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to act upstream of or within protein deubiquitination. Predicted to be active in Golgi apparatus. Orthologous to human USP32 (ubiquitin specific peptidase 32). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See usp32 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23816945..23908741, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (23883827..23973499, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:ch211-167j9.5 Neighboring gene intraflagellar transport 20 homolog (Chlamydomonas) Neighboring gene transmembrane protein 97 Neighboring gene si:ch1073-145m9.1 Neighboring gene amyloid beta precursor protein (cytoplasmic tail) binding protein 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development. Kuil LE, et al. PLoS Genet, 2021 Aug. PMID 34358225, Free PMC Article
    2. Genome Sequencing of the Japanese Eel (Anguilla japonica) for Comparative Genomic Studies on tbx4 and a tbx4 Gene Cluster in Teleost Fishes. Chen W, et al. Mar Drugs, 2019 Jul 20. PMID 31330852, Free PMC Article
    3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 32
    XP_068069823.1
    XP_068069824.1
    XP_068069825.1
    XP_686236.6

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      23816945..23908741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213723.1 → XP_068069824.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B4G2

    2. XM_681144.10 → XP_686236.6  ubiquitin carboxyl-terminal hydrolase 32 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B4G2, A0A8N7T783, E7FCR5
      Related
      ENSDARP00000083241.4, ENSDART00000088808.6
      Conserved Domains (7) summary
      COG5560
      Location:521 → 1546
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:237 → 293
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:1220 → 1546
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:519 → 586
      DUSP; DUSP domain
      pfam13499
      Location:236 → 293
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:623 → 710
      Ubiquitin_3; Ubiquitin-like domain
      cl08302
      Location:270 → 338
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. XM_068213722.1 → XP_068069823.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B4G2

    4. XM_068213724.1 → XP_068069825.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X4

      UniProtKB/TrEMBL
      A0A8M3ASU9
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools