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    PRSS21 serine protease 21 [ Homo sapiens (human) ]

    Gene ID: 10942, updated on 3-Dec-2024

    Summary

    Official Symbol
    PRSS21provided by HGNC
    Official Full Name
    serine protease 21provided by HGNC
    Primary source
    HGNC:HGNC:9485
    See related
    Ensembl:ENSG00000007038 MIM:608159; AllianceGenome:HGNC:9485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESP1; ESP-1; TEST1; TESTISIN
    Summary
    This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in testis (RPKM 26.0), bone marrow (RPKM 4.4) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRSS21 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2817237..2821719)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2837810..2842292)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2867238..2871720)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 3C Neighboring gene serine protease 41 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2852262-2853224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2861337-2862067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2862068-2862797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2864940-2865440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2870033-2870534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2870535-2871034 Neighboring gene eukaryotic translation initiation factor 1 pseudogene 4 Neighboring gene zymogen granule protein 16B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PRSS21 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag Depletion of the PRSS21 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    testisin
    Names
    eosinophil serine protease 1
    protease, serine 21
    serine protease from eosinophils

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270452.2 → NP_001257381.1  testisin isoform 4 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses two alternate splice sites in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA860356, AB031331, BI827608, BX454526
      UniProtKB/TrEMBL
      I3L0U2
      Related
      ENSP00000458341.1, ENST00000574813.5
      Conserved Domains (2) summary
      smart00020
      Location:41 → 194
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:42 → 184
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_006799.4 → NP_006790.1  testisin isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_006790.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB031331, AF058300
      Consensus CDS
      CCDS10478.1
      UniProtKB/Swiss-Prot
      Q9NS34, Q9P2V6, Q9Y6M0
      UniProtKB/TrEMBL
      I3L3C7
      Related
      ENSP00000005995.3, ENST00000005995.8
      Conserved Domains (1) summary
      cd00190
      Location:42 → 283
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. NM_144956.3 → NP_659205.1  testisin isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_659205.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA860356, AB031331, BI334059, BX454526
      UniProtKB/TrEMBL
      I3L3C7
      Related
      ENSP00000460351.1, ENST00000574265.1
      Conserved Domains (2) summary
      smart00020
      Location:41 → 279
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:42 → 281
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. NM_144957.3 → NP_659206.1  testisin isoform 3 preproprotein

      See identical proteins and their annotated locations for NP_659206.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AA860356, AB031331, BX454526, CB529999
      Consensus CDS
      CCDS45388.1
      UniProtKB/TrEMBL
      I3L3C7
      Related
      ENSP00000407741.3, ENST00000450020.7
      Conserved Domains (2) summary
      smart00020
      Location:41 → 267
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:42 → 269
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RNA

    1. NR_073012.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA860356, AB031331, BG717268, BX454526

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      2817237..2821719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433518.1 → XP_047289474.1  testisin isoform X6

      UniProtKB/TrEMBL
      I3L0U2
    2. XM_017022876.2 → XP_016878365.1  testisin isoform X2

    3. XM_017022878.2 → XP_016878367.1  testisin isoform X4

      UniProtKB/TrEMBL
      I3L0U2
    4. XM_047433517.1 → XP_047289473.1  testisin isoform X5

      UniProtKB/TrEMBL
      I3L0U2
    5. XM_047433519.1 → XP_047289475.1  testisin isoform X7

      UniProtKB/TrEMBL
      I3L0U2
    6. XM_017022875.2 → XP_016878364.1  testisin isoform X1

      UniProtKB/TrEMBL
      I3L3C7
    7. XM_017022877.2 → XP_016878366.1  testisin isoform X3

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_013171812.1 Reference GRCh38.p14 PATCHES

      Range
      419..1184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      2837810..2842292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379419.1 → XP_054235394.1  testisin isoform X6

      UniProtKB/TrEMBL
      I3L0U2
    2. XM_054379415.1 → XP_054235390.1  testisin isoform X2

    3. XM_054379417.1 → XP_054235392.1  testisin isoform X4

      UniProtKB/TrEMBL
      I3L0U2
    4. XM_054379418.1 → XP_054235393.1  testisin isoform X5

      UniProtKB/TrEMBL
      I3L0U2
    5. XM_054379420.1 → XP_054235395.1  testisin isoform X7

      UniProtKB/TrEMBL
      I3L0U2
    6. XM_054379414.1 → XP_054235389.1  testisin isoform X1

      UniProtKB/TrEMBL
      I3L3C7
    7. XM_054379416.1 → XP_054235391.1  testisin isoform X3