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    LGALS13 galectin 13 [ Homo sapiens (human) ]

    Gene ID: 29124, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LGALS13provided by HGNC
    Official Full Name
    galectin 13provided by HGNC
    Primary source
    HGNC:HGNC:15449
    See related
    Ensembl:ENSG00000105198 MIM:608717; AllianceGenome:HGNC:15449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP13; GAL13; PLAC8
    Summary
    Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward placenta (RPKM 6.7) See more
    Orthologs
    all
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    Genomic context

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    See LGALS13 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39602524..39607474)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42406672..42411734)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40093164..40098114)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 pseudogene 25 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:40086129-40087328 Neighboring gene MPRA-validated peak3478 silencer Neighboring gene ribosomal protein S29 pseudogene 26 Neighboring gene galectin 14 pseudogene Neighboring gene ribosomal protein S29 pseudogene 30

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Placental protein 13 and decidual zones of necrosis: an immunologic diversion that may be linked to preeclampsia. Kliman HJ, et al. Reprod Sci, 2012 Jan. PMID 21989657
    2. First-trimester maternal serum PP13 in the risk assessment for preeclampsia. Romero R, et al. Am J Obstet Gynecol, 2008 Aug. PMID 18539259, Free PMC Article
    3. Placental protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre-eclampsia and HELLP syndrome. Than NG, et al. Virchows Arch, 2008 Oct. PMID 18791734, Free PMC Article
    4. Prediction of preeclampsia by placental protein 13 and background risk factors and its prevention by aspirin. Meiri H, et al. J Perinat Med, 2014 Sep. PMID 24607918
    5. First trimester maternal serum placental protein 13 levels in singleton vs. twin pregnancies with and without severe pre-eclampsia. Svirsky R, et al. J Perinat Med, 2013 Sep 1. PMID 23729534

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Placental Protein 13 and Syncytiotrophoblast Basement Membrane Ultrastructures in Preeclampsia.
      Title: Placental Protein 13 and Syncytiotrophoblast Basement Membrane Ultrastructures in Preeclampsia.
    2. [Predictive value of serum Gal-13, GLP-1 and VEGF levels in adverse pregnancy outcomes of gestational diabetes mellitus].
      Title: [Predictive value of serum Gal-13, GLP-1 and VEGF levels in adverse pregnancy outcomes of gestational diabetes mellitus].
    3. Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection-associated spontaneous preterm birth.
      Title: Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection-associated spontaneous preterm birth.
    4. Augmented Placental Protein 13 in Placental-Associated Extracellular Vesicles in Term and Preterm Preeclampsia Is Further Elevated by Corticosteroids.
      Title: Augmented Placental Protein 13 in Placental-Associated Extracellular Vesicles in Term and Preterm Preeclampsia Is Further Elevated by Corticosteroids.
    5. Association between Galectin-13 Expression and Eosinophilic Airway Inflammation in Chronic Obstructive Pulmonary Disease.
      Title: Association between Galectin-13 Expression and Eosinophilic Airway Inflammation in Chronic Obstructive Pulmonary Disease.
    6. PLACENTAL BIOMARKERS: PP13, VEGF IN DIAGNOSTICS OF EARLY AND LATE PREECLAMPSIA.
      Title: PLACENTAL BIOMARKERS: PP13, VEGF IN DIAGNOSTICS OF EARLY AND LATE PREECLAMPSIA.
    7. [Expression of galectin-13 in allergic diseases involving airway, skin and mucous membranes].
      Title: [Expression of galectin-13 in allergic diseases involving airway, skin and mucous membranes].
    8. Increased epithelial galectin-13 expression associates with eosinophilic airway inflammation in asthma.
      Title: Increased epithelial galectin-13 expression associates with eosinophilic airway inflammation in asthma.
    9. Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype.
      Title: Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype.
    10. Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution.
      Title: Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    galactoside-binding soluble lectin 13
    Names
    beta-galactoside-binding lectin
    gal-13
    lectin, galactoside-binding, soluble, 13
    placental protein 13
    placental tissue protein 13
    NP_037400.1
    XP_011525176.2
    XP_024307242.1
    XP_054176728.1
    XP_054176729.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013268.3 → NP_037400.1  galactoside-binding soluble lectin 13

      See identical proteins and their annotated locations for NP_037400.1

      Status: REVIEWED

      Source sequence(s)
      AC005205
      Consensus CDS
      CCDS33024.1
      UniProtKB/Swiss-Prot
      C5HZ15, Q9UHV8
      Related
      ENSP00000221797.3, ENST00000221797.5
      Conserved Domains (1) summary
      smart00908
      Location:11 → 135
      Gal-bind_lectin; Galactoside-binding lectin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39602524..39607474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451474.2 → XP_024307242.1  galactoside-binding soluble lectin 13 isoform X2

      Conserved Domains (1) summary
      smart00908
      Location:42 → 166
      Gal-bind_lectin; Galactoside-binding lectin

    2. XM_011526874.3 → XP_011525176.2  galactoside-binding soluble lectin 13 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42406672..42411734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320754.1 → XP_054176729.1  galactoside-binding soluble lectin 13 isoform X2

    2. XM_054320753.1 → XP_054176728.1  galactoside-binding soluble lectin 13 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UHV8.1 GenPept UniProtKB/Swiss-Prot:Q9UHV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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