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    FBXW9 F-box and WD repeat domain containing 9 [ Homo sapiens (human) ]

    Gene ID: 84261, updated on 9-Dec-2024

    Summary

    Official Symbol
    FBXW9provided by HGNC
    Official Full Name
    F-box and WD repeat domain containing 9provided by HGNC
    Primary source
    HGNC:HGNC:28136
    See related
    Ensembl:ENSG00000132004 MIM:609074; AllianceGenome:HGNC:28136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fbw9; MEC-15
    Summary
    Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 5.8), kidney (RPKM 2.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See FBXW9 in Genome Data Viewer
    Location:
    19p13.13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12688916..12696631, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12813416..12821121, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12799730..12807445, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-FlowFISH-validated DHPS regulatory element Neighboring gene WD repeat domain 83 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14071 Neighboring gene deoxyhypusine synthase Neighboring gene CRISPRi-FlowFISH-validated WDR83OS regulatory elements Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12793915-12794437 Neighboring gene G protein subunit gamma 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14073 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:12811952-12813151 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12813649-12814258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12814259-12814867 Neighboring gene transportin 2 Neighboring gene small nucleolar RNA, C/D box 135 Neighboring gene small nucleolar RNA, C/D box 41

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    F-box/WD repeat-containing protein 9
    Names
    F-box and WD-40 domain protein 9
    F-box and WD-40 domain-containing protein 9
    F-box and WD-40 repeat containing protein 9
    specificity factor for SCF ubiquitin ligase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032301.3NP_115677.2  F-box/WD repeat-containing protein 9

      Status: VALIDATED

      Source sequence(s)
      AK123037, AW083348, DA079240
      Consensus CDS
      CCDS12278.2
      UniProtKB/Swiss-Prot
      B3KVP7, Q5XUX1, Q9BT89
      Related
      ENSP00000376945.3, ENST00000393261.8
      Conserved Domains (2) summary
      sd00039
      Location:177222
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:170413
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12688916..12696631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260096.5XP_005260153.1  F-box/WD repeat-containing protein 9 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:20294
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:6499
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:17250
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12813416..12821121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322334.1XP_054178309.1  F-box/WD repeat-containing protein 9 isoform X1