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    IL17C interleukin 17C [ Homo sapiens (human) ]

    Gene ID: 27189, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IL17Cprovided by HGNC
    Official Full Name
    interleukin 17Cprovided by HGNC
    Primary source
    HGNC:HGNC:5983
    See related
    Ensembl:ENSG00000124391 MIM:604628; AllianceGenome:HGNC:5983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CX2; IL-17C
    Summary
    The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in endometrium (RPKM 1.7), gall bladder (RPKM 0.2) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See IL17C in Genome Data Viewer
    Location:
    16q24.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (88638572..88640468)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (94706451..94708347)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88704980..88706876)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11356 Neighboring gene zinc finger CCCH-type containing 18 Neighboring gene Sharpr-MPRA regulatory region 13594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11357 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:88673559-88674059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88676553-88677498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88694002-88694718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88694719-88695433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88701182-88702111 Neighboring gene uncharacterized LOC124903755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88707025-88707852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11359 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88715799-88716694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88716695-88717588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88717589-88718483 Neighboring gene cytochrome b-245 alpha chain Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7865 Neighboring gene mevalonate diphosphate decarboxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube. Garcia EM, et al. Nat Commun, 2024 May 4. PMID 38704381, Free PMC Article
    2. Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium. Swedik SM, et al. J Immunol, 2022 Nov 1. PMID 36130829, Free PMC Article
    3. IL-17C expression and its correlation with pediatric adenoids: a preliminary study. Min HJ, et al. Int J Med Sci, 2020. PMID 33162788, Free PMC Article
    4. Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells. Jamieson KC, et al. Front Cell Infect Microbiol, 2020. PMID 32232015, Free PMC Article
    5. Presence of interleukin-17C in the tissue around aseptic loosened implants. Hou C, et al. Int Orthop, 2013 May. PMID 23474800, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube.
      Title: IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube.
    2. IL-17C neutralization protects the kidney against acute injury and chronic injury.
      Title: IL-17C neutralization protects the kidney against acute injury and chronic injury.
    3. Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium.
      Title: Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium.
    4. Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19.
      Title: Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19.
    5. IL-17C expression and its correlation with pediatric adenoids: a preliminary study.
      Title: IL-17C expression and its correlation with pediatric adenoids: a preliminary study.
    6. Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells.
      Title: Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells.
    7. IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.
      Title: IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.
    8. IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology.
      Title: IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.
    9. IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer.
      Title: IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer.
    10. Patients with acute Anti-neutrophil cytoplasmatic antibody (ANCA)-associated crescentic glomerulonephritis (GN) had significantly elevated serum levels of IL-17C.
      Title: IL-17C/IL-17 Receptor E Signaling in CD4(+) T Cells Promotes T(H)17 Cell-Driven Glomerular Inflammation.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126884, MGC138401

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-17C
    Names
    cytokine CX2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013278.4 → NP_037410.1  interleukin-17C precursor

      Status: REVIEWED

      Source sequence(s)
      AC116552
      Consensus CDS
      CCDS42217.1
      UniProtKB/Swiss-Prot
      Q3MIG8, Q9HC75, Q9P0M4
      Related
      ENSP00000244241.4, ENST00000244241.5
      Conserved Domains (1) summary
      pfam06083
      Location:104 → 192
      IL17; Interleukin-17

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      88638572..88640468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      94706451..94708347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P0M4.1 GenPept UniProtKB/Swiss-Prot:Q9P0M4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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