U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FBXO22 F-box protein 22 [ Homo sapiens (human) ]

    Gene ID: 26263, updated on 9-Dec-2024

    Summary

    Official Symbol
    FBXO22provided by HGNC
    Official Full Name
    F-box protein 22provided by HGNC
    Primary source
    HGNC:HGNC:13593
    See related
    Ensembl:ENSG00000167196 MIM:609096; AllianceGenome:HGNC:13593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX22; FISTC1
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in prostate (RPKM 5.0), kidney (RPKM 4.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FBXO22 in Genome Data Viewer
    Location:
    15q24.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (75903878..75942511)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (73774621..73813245)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (76196219..76234852)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76084438-76084938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76084939-76085439 Neighboring gene dynamin 1 pseudogene 49 Neighboring gene Sharpr-MPRA regulatory region 8353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6683 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:76135870-76136767 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:76163679-76164628 Neighboring gene ubiquitin conjugating enzyme E2 Q2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:76196047-76196704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:76195387-76196046 Neighboring gene RNA, 7SL, cytoplasmic 510, pseudogene Neighboring gene uncharacterized LOC124903616 Neighboring gene neuregulin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76311273-76311774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6687 Neighboring gene transmembrane protein 266 Neighboring gene uncharacterized LOC124903531

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13986, MGC31799

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    F-box only protein 22
    Names
    F-box protein FBX22p44
    FIST domain containing 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012170.4NP_036302.1  F-box only protein 22 isoform b

      See identical proteins and their annotated locations for NP_036302.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a distinct 3' coding sequence and 3' UTR compared to variant 1. This results in a shorter isoform (b) with a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC027104, AK024048, AL705285
      Consensus CDS
      CCDS45310.1
      UniProtKB/Swiss-Prot
      Q8NEZ5
      Related
      ENSP00000396442.2, ENST00000453211.6
      Conserved Domains (1) summary
      pfam12937
      Location:2858
      F-box-like; F-box-like
    2. NM_147188.3NP_671717.1  F-box only protein 22 isoform a

      See identical proteins and their annotated locations for NP_671717.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC027104, AW292124, BC020204
      Consensus CDS
      CCDS10287.1
      UniProtKB/Swiss-Prot
      Q0D2P8, Q6PIL5, Q8IXW3, Q8NEZ5, Q9H824, Q9UKC0
      UniProtKB/TrEMBL
      Q53EY9
      Related
      ENSP00000307833.3, ENST00000308275.8
      Conserved Domains (2) summary
      pfam10442
      Location:301364
      FIST_C; FIST C domain
      pfam12937
      Location:2858
      F-box-like; F-box-like

    RNA

    1. NR_037623.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC027104, AW292124, BC020204, BC039024

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      75903878..75942511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432382.1XP_047288338.1  F-box only protein 22 isoform X1

      UniProtKB/TrEMBL
      B4DFX7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      73774621..73813245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377720.1XP_054233695.1  F-box only protein 22 isoform X1

      UniProtKB/TrEMBL
      B4DFX7