FER FER tyrosine kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: FERprovided by HGNC
Official Full Name: FER tyrosine kinaseprovided by HGNC
Primary source: HGNC:HGNC:3655
See related: Ensembl:ENSG00000151422 MIM:176942; AllianceGenome:HGNC:3655
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TYK3; PPP1R74; p94-Fer
Summary: The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]
Expression: Ubiquitous expression in thyroid (RPKM 2.8), testis (RPKM 2.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q21.3

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (108747897..109196841)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (109250514..109700301)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (108083598..108532542)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells.
Title: FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells.
Phosphorylation of PKCdelta by FER tips the balance from EGFR degradation to recycling.
Title: Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling.
Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells.
Title: Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells.
FER mediated HGF-independent regulation of HGFR/MET activates RAC1-PAK1 pathway to potentiate metastasis in ovarian cancer.
Title: FER mediated HGF-independent regulation of HGFR/MET activates RAC1-PAK1 pathway to potentiate metastasis in ovarian cancer.
Loss of Fer Jeopardizes Metabolic Plasticity and Mitochondrial Homeostasis in Lung and Breast Carcinoma Cells.
Title: Loss of Fer Jeopardizes Metabolic Plasticity and Mitochondrial Homeostasis in Lung and Breast Carcinoma Cells.
This study supports the critical role of FER and FES tyrosine kinase fusions in the pathogenesis of follicular T-cell lymphoma and provides additional evidence that these can drive follicular T-cell lymphoma in the absence of RHOA mutations.
Title: FER and FES tyrosine kinase fusions in follicular T-cell lymphoma.
Targeting of both FER and MET may be an effective strategy for therapeutic intervention in ovarian cancer.
Title: Spatial regulation of signaling by the coordinated action of the protein tyrosine kinases MET and FER.
The FER rs4957796 TT genotype remained a significant covariate for the 90-day mortality risk in the multivariate analysis (hazard ratio, 4.62; 95% CI, 1.58-13.50; p = 0.0050). In conclusion, FER rs4957796 might act as a prognostic variable for survival in patients with severe ARDS due to pneumonia.
Title: The FER rs4957796 TT genotype is associated with unfavorable 90-day survival in Caucasian patients with severe ARDS due to pneumonia.
FER enhances IGF-1R expression, phosphorylation, and signaling to promote cooperative growth and adhesion signaling that may facilitate cancer progression.
Title: FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion.
FER overexpression improves survival through STAT activation enhancing innate immunity and accelerating bacterial clearance in the lung.
Title: Electroporation-mediated delivery of FER gene enhances innate immune response and improves survival in a murine model of pneumonia.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel locus FER is associated with serum HMW adiponectin levels. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH27497 (e-PCR)
- UniSTS:90137

SHGC-31298 (e-PCR)
- UniSTS:21057

WI-6988 (e-PCR)
- UniSTS:20556

D5S1763 (e-PCR)
- UniSTS:79200

RH68965 (e-PCR)
- UniSTS:41338

SHGC-80885 (e-PCR)
- UniSTS:102528

RH71338 (e-PCR)
- UniSTS:47265

SHGC-101669 (e-PCR)
- UniSTS:183971

HSC2MH092 (e-PCR)
- UniSTS:28071

RH66216 (e-PCR)
- UniSTS:25040

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Fc-epsilon receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Fc-epsilon receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in Kit signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in Sertoli cell development	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in adherens junction assembly	IEA Inferred from Electronic Annotation more info
involved_in adherens junction disassembly	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to macrophage colony-stimulating factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diapedesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in extracellular matrix-cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-6-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mast cell activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet-derived growth factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fibroblast migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of lamellipodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to platelet-derived growth factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in seminiferous tubule development	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info
involved_in tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
colocalizes_with cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
colocalizes_with lamellipodium	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein kinase Fer

Names: feline encephalitis virus-related kinase FER; fer (fps/fes related) tyrosine kinase; fujinami poultry sarcoma/Feline sarcoma-related protein Fer; phosphoprotein NCP94; protein phosphatase 1, regulatory subunit 74; proto-oncogene c-Fer; tyrosine kinase 3

NP_001294957.1

EC 2.7.10.2

NP_001294960.1

EC 2.7.10.2

NP_001294967.1

EC 2.7.10.2

NP_005237.2

EC 2.7.10.2

XP_011541571.1

EC 2.7.10.2

XP_011541572.1

EC 2.7.10.2

XP_011541578.1

EC 2.7.10.2

XP_016864719.1

EC 2.7.10.2

XP_016864720.1

EC 2.7.10.2

XP_016864722.1

EC 2.7.10.2

XP_047272891.1

EC 2.7.10.2

XP_047272893.1

EC 2.7.10.2

XP_047272894.1

EC 2.7.10.2

XP_047272895.1

EC 2.7.10.2

XP_047272896.1

EC 2.7.10.2

XP_047272897.1

EC 2.7.10.2

XP_047272898.1

EC 2.7.10.2

XP_047272900.1

EC 2.7.10.2

XP_047272901.1

EC 2.7.10.2

XP_047272902.1

EC 2.7.10.2

XP_047272903.1

EC 2.7.10.2

XP_054208030.1

EC 2.7.10.2

XP_054208031.1

EC 2.7.10.2

XP_054208032.1

EC 2.7.10.2

XP_054208033.1

EC 2.7.10.2

XP_054208034.1

EC 2.7.10.2

XP_054208035.1

EC 2.7.10.2

XP_054208036.1

EC 2.7.10.2

XP_054208037.1

EC 2.7.10.2

XP_054208038.1

EC 2.7.10.2

XP_054208039.1

EC 2.7.10.2

XP_054208040.1

EC 2.7.10.2

XP_054208041.1

EC 2.7.10.2

XP_054208042.1

EC 2.7.10.2

XP_054208043.1

EC 2.7.10.2

XP_054208044.1

EC 2.7.10.2

XP_054208045.1

EC 2.7.10.2

XP_054208046.1

EC 2.7.10.2

XP_054208047.1

EC 2.7.10.2

XP_054208048.1

EC 2.7.10.2

XP_054208049.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011445.2 RefSeqGene

Range

5076..454020

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001308028.2 → NP_001294957.1 tyrosine-protein kinase Fer isoform b

See identical proteins and their annotated locations for NP_001294957.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AC116428, AK299855, AK315234, AL707447, BQ009328, J03358

UniProtKB/TrEMBL

W0S1B5

Conserved Domains (4) summary

cd10361
Location:278 → 363

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cd05085
Location:391 → 641

PTKc_Fer; Catalytic domain of the Protein Tyrosine Kinase, Fer

pfam07714
Location:388 → 639

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:1 → 63

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001308031.2 → NP_001294960.1 tyrosine-protein kinase Fer isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks several 5' exons but contains an alternate 5' terminal exon derived from the use of an internal promoter, and it thus differs in the 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (c, also known as FerT) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AC008955, AC116428, BQ009328, BU155168, J03358, JQ412173

Consensus CDS

CCDS78044.1

UniProtKB/TrEMBL

W0S4B9

Related

ENSP00000484767.1, ENST00000618353.1

Conserved Domains (3) summary

cd10361
Location:84 → 169

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cd05085
Location:197 → 447

PTKc_Fer; Catalytic domain of the Protein Tyrosine Kinase, Fer

pfam07714
Location:194 → 445

Pkinase_Tyr; Protein tyrosine kinase
NM_001308038.2 → NP_001294967.1 tyrosine-protein kinase Fer isoform d

See identical proteins and their annotated locations for NP_001294967.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, and lacks several exons in the central and 3' coding regions but instead contains alternate 3' exon structure, thereby differing in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.

Source sequence(s)

AC008871, AK315234, AL707447, BC058030

UniProtKB/TrEMBL

Q6PEJ9

Related

ENST00000502752.1

Conserved Domains (1) summary

cl12013
Location:5 → 163

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_005246.4 → NP_005237.2 tyrosine-protein kinase Fer isoform a

See identical proteins and their annotated locations for NP_005237.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as p94-Fer or FerS).

Source sequence(s)

AC116428, AK315234, BQ009328, J03358

Consensus CDS

CCDS4098.1

UniProtKB/Swiss-Prot

B2RCR4, B4DSQ2, H2FLB8, P16591

UniProtKB/TrEMBL

W0S0X4

Related

ENSP00000281092.4, ENST00000281092.9

Conserved Domains (3) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:453 → 538

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:566 → 816

PKc_like; Protein Kinases, catalytic domain

RNA

NR_146155.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate 5' exon and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC109481, AC116428, AK315234, AL707447, BQ009328, HY146611, J03358

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

108747897..109196841

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011543269.3 → XP_011541571.1 tyrosine-protein kinase Fer isoform X1

See identical proteins and their annotated locations for XP_011541571.1

Conserved Domains (4) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:453 → 538

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

pfam07714
Location:563 → 829

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:566 → 831

PKc_like; Protein Kinases, catalytic domain
XM_017009231.3 → XP_016864720.1 tyrosine-protein kinase Fer isoform X2

UniProtKB/Swiss-Prot

B2RCR4, B4DSQ2, H2FLB8, P16591

UniProtKB/TrEMBL

W0S0X4

Conserved Domains (3) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:453 → 538

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:566 → 816

PKc_like; Protein Kinases, catalytic domain
XM_047416940.1 → XP_047272896.1 tyrosine-protein kinase Fer isoform X5
XM_047416945.1 → XP_047272901.1 tyrosine-protein kinase Fer isoform X9
XM_011543270.4 → XP_011541572.1 tyrosine-protein kinase Fer isoform X1

See identical proteins and their annotated locations for XP_011541572.1

Conserved Domains (4) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:453 → 538

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

pfam07714
Location:563 → 829

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:566 → 831

PKc_like; Protein Kinases, catalytic domain
XM_017009230.3 → XP_016864719.1 tyrosine-protein kinase Fer isoform X2

UniProtKB/Swiss-Prot

B2RCR4, B4DSQ2, H2FLB8, P16591

UniProtKB/TrEMBL

W0S0X4

Conserved Domains (3) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:453 → 538

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:566 → 816

PKc_like; Protein Kinases, catalytic domain
XM_047416938.1 → XP_047272894.1 tyrosine-protein kinase Fer isoform X3
XM_047416939.1 → XP_047272895.1 tyrosine-protein kinase Fer isoform X5
XM_047416942.1 → XP_047272898.1 tyrosine-protein kinase Fer isoform X7
XM_047416944.1 → XP_047272900.1 tyrosine-protein kinase Fer isoform X8
XM_047416946.1 → XP_047272902.1 tyrosine-protein kinase Fer isoform X11
XM_047416947.1 → XP_047272903.1 tyrosine-protein kinase Fer isoform X12
XM_047416935.1 → XP_047272891.1 tyrosine-protein kinase Fer isoform X1
XM_047416937.1 → XP_047272893.1 tyrosine-protein kinase Fer isoform X2

UniProtKB/Swiss-Prot

B2RCR4, B4DSQ2, H2FLB8, P16591

UniProtKB/TrEMBL

W0S0X4
XM_017009233.3 → XP_016864722.1 tyrosine-protein kinase Fer isoform X4

Conserved Domains (4) summary

cd10361
Location:380 → 465

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

pfam07714
Location:490 → 756

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:1 → 165

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl21453
Location:493 → 758

PKc_like; Protein Kinases, catalytic domain
XM_047416941.1 → XP_047272897.1 tyrosine-protein kinase Fer isoform X6
XM_011543276.3 → XP_011541578.1 tyrosine-protein kinase Fer isoform X10

UniProtKB/TrEMBL

W0S4B9

Conserved Domains (3) summary

cd10361
Location:84 → 169

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

pfam07714
Location:194 → 460

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:197 → 462

PKc_like; Protein Kinases, catalytic domain

RNA

XR_007058589.1 RNA Sequence
XR_007058591.1 RNA Sequence
XR_007058590.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

109250514..109700301

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054352062.1 → XP_054208037.1 tyrosine-protein kinase Fer isoform X13
XM_054352056.1 → XP_054208031.1 tyrosine-protein kinase Fer isoform X1
XM_054352059.1 → XP_054208034.1 tyrosine-protein kinase Fer isoform X2

UniProtKB/Swiss-Prot

B2RCR4, B4DSQ2, H2FLB8, P16591

UniProtKB/TrEMBL

W0S0X4
XM_054352067.1 → XP_054208042.1 tyrosine-protein kinase Fer isoform X5
XM_054352071.1 → XP_054208046.1 tyrosine-protein kinase Fer isoform X9
XM_054352061.1 → XP_054208036.1 tyrosine-protein kinase Fer isoform X13
XM_054352065.1 → XP_054208040.1 tyrosine-protein kinase Fer isoform X14
XM_054352055.1 → XP_054208030.1 tyrosine-protein kinase Fer isoform X1
XM_054352058.1 → XP_054208033.1 tyrosine-protein kinase Fer isoform X2

UniProtKB/Swiss-Prot

B2RCR4, B4DSQ2, H2FLB8, P16591

UniProtKB/TrEMBL

W0S0X4
XM_054352063.1 → XP_054208038.1 tyrosine-protein kinase Fer isoform X3
XM_054352066.1 → XP_054208041.1 tyrosine-protein kinase Fer isoform X5
XM_054352069.1 → XP_054208044.1 tyrosine-protein kinase Fer isoform X7
XM_054352070.1 → XP_054208045.1 tyrosine-protein kinase Fer isoform X8
XM_054352073.1 → XP_054208048.1 tyrosine-protein kinase Fer isoform X11
XM_054352074.1 → XP_054208049.1 tyrosine-protein kinase Fer isoform X12
XM_054352057.1 → XP_054208032.1 tyrosine-protein kinase Fer isoform X1
XM_054352060.1 → XP_054208035.1 tyrosine-protein kinase Fer isoform X2

UniProtKB/Swiss-Prot

B2RCR4, B4DSQ2, H2FLB8, P16591

UniProtKB/TrEMBL

W0S0X4
XM_054352064.1 → XP_054208039.1 tyrosine-protein kinase Fer isoform X4
XM_054352068.1 → XP_054208043.1 tyrosine-protein kinase Fer isoform X6
XM_054352072.1 → XP_054208047.1 tyrosine-protein kinase Fer isoform X10