U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SLC26A8 solute carrier family 26 member 8 [ Homo sapiens (human) ]

    Gene ID: 116369, updated on 27-Nov-2024

    Summary

    Official Symbol
    SLC26A8provided by HGNC
    Official Full Name
    solute carrier family 26 member 8provided by HGNC
    Primary source
    HGNC:HGNC:14468
    See related
    Ensembl:ENSG00000112053 MIM:608480; AllianceGenome:HGNC:14468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AZON; TAT1; SPGF3
    Summary
    This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]
    Expression
    Restricted expression toward testis (RPKM 27.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC26A8 in Genome Data Viewer
    Location:
    6p21.31
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (35943516..36024641, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (35763833..35844951, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35911293..35992418, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17101 Neighboring gene LHFPL tetraspan subfamily member 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:35810876-35811031 Neighboring gene uncharacterized LOC124901311 Neighboring gene SRSF protein kinase 1 Neighboring gene MPRA-validated peak5780 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17103 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35899139-35899789 Neighboring gene uncharacterized LOC105375035 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:35960877-35961390 Neighboring gene uncharacterized LOC105375034 Neighboring gene divergent-paired related homeobox pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35991863-35992364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35992365-35992864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24415 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17104 Neighboring gene Sharpr-MPRA regulatory region 2026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17105 Neighboring gene mitogen-activated protein kinase 14 Neighboring gene NUDT5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36098441-36099044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36106471-36106971 Neighboring gene mitogen-activated protein kinase 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32714

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxalate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sulfate:chloride antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oxalate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm annulus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    testis anion transporter 1
    Names
    anion transporter/exchanger-8
    solute carrier family 26 (anion exchanger), member 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033897.1 RefSeqGene

      Range
      4996..86121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001193476.2NP_001180405.1  testis anion transporter 1 isoform a

      See identical proteins and their annotated locations for NP_001180405.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AF331522, AK122928, AL133507, Z95152
      Consensus CDS
      CCDS4813.1
      UniProtKB/Swiss-Prot
      Q5JVR5, Q812C7, Q8TC65, Q96MA0, Q96PK8, Q96RN1
      Related
      ENSP00000347778.2, ENST00000355574.6
      Conserved Domains (3) summary
      cd07042
      Location:719776
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:92493
      Sulfate_transp; Sulfate permease family
      cl00604
      Location:544584
      STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors
    2. NM_052961.4NP_443193.1  testis anion transporter 1 isoform a

      See identical proteins and their annotated locations for NP_443193.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AF331522, AL133507, Z95152
      Consensus CDS
      CCDS4813.1
      UniProtKB/Swiss-Prot
      Q5JVR5, Q812C7, Q8TC65, Q96MA0, Q96PK8, Q96RN1
      Related
      ENSP00000417638.1, ENST00000490799.6
      Conserved Domains (3) summary
      cd07042
      Location:719776
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:92493
      Sulfate_transp; Sulfate permease family
      cl00604
      Location:544584
      STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors
    3. NM_138718.3NP_619732.2  testis anion transporter 1 isoform b

      See identical proteins and their annotated locations for NP_619732.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks two exons in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.
      Source sequence(s)
      AL133507, BC025408, Z95152
      Consensus CDS
      CCDS4814.1
      UniProtKB/Swiss-Prot
      Q96RN1
      Related
      ENSP00000378100.2, ENST00000394602.6
      Conserved Domains (3) summary
      cd07042
      Location:614671
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:92388
      Sulfate_transp; Sulfate permease family
      cl00604
      Location:439479
      STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      35943516..36024641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514294.4XP_011512596.1  testis anion transporter 1 isoform X2

      Conserved Domains (3) summary
      cd07042
      Location:693750
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:92467
      Sulfate_transp; Sulfate permease family
      cl00604
      Location:518558
      STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors
    2. XM_017010235.2XP_016865724.1  testis anion transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5JVR5, Q812C7, Q8TC65, Q96MA0, Q96PK8, Q96RN1
      Conserved Domains (3) summary
      cd07042
      Location:719776
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:92493
      Sulfate_transp; Sulfate permease family
      cl00604
      Location:544584
      STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors

    RNA

    1. XR_926055.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      35763833..35844951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354191.1XP_054210166.1  testis anion transporter 1 isoform X2

    2. XM_054354190.1XP_054210165.1  testis anion transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5JVR5, Q812C7, Q8TC65, Q96MA0, Q96PK8, Q96RN1

    RNA

    1. XR_008487252.1 RNA Sequence