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    NUDT10 nudix hydrolase 10 [ Homo sapiens (human) ]

    Gene ID: 170685, updated on 9-Dec-2024

    Summary

    Official Symbol
    NUDT10provided by HGNC
    Official Full Name
    nudix hydrolase 10provided by HGNC
    Primary source
    HGNC:HGNC:17621
    See related
    Ensembl:ENSG00000122824 MIM:300527; AllianceGenome:HGNC:17621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APS2; DIPP3a; DIPP3-alpha
    Summary
    This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]
    Expression
    Biased expression in testis (RPKM 20.6), brain (RPKM 8.6) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NUDT10 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (51332231..51337525)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (50603515..50608810)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (51075083..51080377)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene acyl-coenzyme A synthetase ACSM6, mitochondrial-like Neighboring gene long intergenic non-protein coding RNA 1284 Neighboring gene MAGE family member A10 pseudogene Neighboring gene uncharacterized LOC105373204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:51004797-51005298 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:51022229-51022780 Neighboring gene centromere protein V pseudogene Neighboring gene EZH inhibitory protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
    EBI GWAS Catalog
    Multiple newly identified loci associated with prostate cancer susceptibility.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bis(5'-adenosyl)-hexaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables bis(5'-adenosyl)-pentaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables diphosphoinositol-polyphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables diphosphoinositol-polyphosphate diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables endopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diadenosine hexaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diadenosine pentaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diphosphoinositol polyphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    diphosphoinositol polyphosphate phosphohydrolase 3-alpha
    Names
    diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha
    diadenosine hexaphosphate hydrolase (AMP-forming)
    nucleoside diphosphate-linked moiety X motif 10
    nudix (nucleoside diphosphate linked moiety X)-type motif 10
    nudix motif 10
    NP_001291892.1
    NP_694853.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304963.2NP_001291892.1  diphosphoinositol polyphosphate phosphohydrolase 3-alpha

      See identical proteins and their annotated locations for NP_001291892.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC049383, BC050700, BX449265, CN399689
      Consensus CDS
      CCDS35278.1
      UniProtKB/Swiss-Prot
      A8K7D7, D3DX69, Q86VK1, Q86VR0, Q8NFP7
      UniProtKB/TrEMBL
      B2RE29
      Related
      ENSP00000348831.2, ENST00000356450.3
      Conserved Domains (1) summary
      cd04666
      Location:18137
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    2. NM_153183.4NP_694853.1  diphosphoinositol polyphosphate phosphohydrolase 3-alpha

      See identical proteins and their annotated locations for NP_694853.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC233976, AF469196, AK291952
      Consensus CDS
      CCDS35278.1
      UniProtKB/Swiss-Prot
      A8K7D7, D3DX69, Q86VK1, Q86VR0, Q8NFP7
      UniProtKB/TrEMBL
      B2RE29
      Related
      ENSP00000365174.3, ENST00000376006.7
      Conserved Domains (1) summary
      cd04666
      Location:18137
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      51332231..51337525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      50603515..50608810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)