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    CTF8 Ctf8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856598, updated on 3-Nov-2024

    Summary

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    Official Symbol
    CTF8
    Official Full Name
    Ctf8p
    Primary source
    SGD:S000001234
    Locus tag
    YHR191C
    See related
    AllianceGenome:SGD:S000001234; FungiDB:YHR191C; VEuPathDB:YHR191C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA binding activity. Involved in maintenance of DNA trinucleotide repeats and mitotic sister chromatid cohesion. Acts upstream of or within telomere tethering at nuclear periphery. Part of Ctf18 RFC-like complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CTF8 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (486230..486631, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene aminoacyl-tRNA hydrolase Neighboring gene bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase Neighboring gene Lnp1p Neighboring gene Egd2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time. Hiraga S, et al. EMBO J, 2006 Apr 5. PMID 16525505, Free PMC Article
    2. An Smc3 acetylation cycle is essential for establishment of sister chromatid cohesion. Beckouët F, et al. Mol Cell, 2010 Sep 10. PMID 20832721, Free PMC Article
    3. Mutability and mutational spectrum of chromosome transmission fidelity genes. Stirling PC, et al. Chromosoma, 2012 Jun. PMID 22198145, Free PMC Article
    4. Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II. Petronczki M, et al. J Cell Sci, 2004 Jul 15. PMID 15226378
    5. Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability in Saccharomyces cerevisiae. Okimoto H, et al. Genes Cells, 2016 May. PMID 26987677

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of DNA trinucleotide repeats IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within telomere tethering at nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ctf18 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ctf8p
    NP_012061.3
    • Subunit of a complex with Ctf18p; shares some subunits with Replication Factor C; required for sister chromatid cohesion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      486230..486631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179322.3 → NP_012061.3  TPA: Ctf8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012061.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLD9, P38877
      UniProtKB/TrEMBL
      A6ZT97, B3LSV2, C7GRL3, C8Z9Z0, G2WFR4, N1P2J0
      Conserved Domains (1) summary
      pfam09696
      Location:29 → 132
      Ctf8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38877.1

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