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    ERV25 Erv25p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854997, updated on 1-Aug-2024

    Summary

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    Gene symbol
    ERV25
    Gene description
    Erv25p
    Primary source
    FungiDB:YML012W
    Locus tag
    YML012W
    See related
    SGD:S000004473; AllianceGenome:SGD:S000004473; VEuPathDB:YML012W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in COPII-coated ER to Golgi transport vesicle. Orthologous to human TMED10 (transmembrane p24 trafficking protein 10). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ERV25 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (246116..246751)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene tRNA (carboxymethyluridine(34)-5-O)-methyltransferase Neighboring gene Ubx2p Neighboring gene Rad33p Neighboring gene transcription elongation factor SPT5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a lumenal sequence specifying the assembly of Emp24p into p24 complexes in the yeast secretory pathway. Ciufo LF, et al. J Biol Chem, 2000 Mar 24. PMID 10722670
    2. Erv25p, a component of COPII-coated vesicles, forms a complex with Emp24p that is required for efficient endoplasmic reticulum to Golgi transport. Belden WJ, et al. J Biol Chem, 1996 Oct 25. PMID 8900179
    3. The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles. Muñiz M, et al. J Cell Biol, 2000 Mar 6. PMID 10704443, Free PMC Article
    4. The Erv41p-Erv46p complex: multiple export signals are required in trans for COPII-dependent transport from the ER. Otte S, et al. EMBO J, 2002 Nov 15. PMID 12426381, Free PMC Article
    5. The yeast p24 complex is required for the formation of COPI retrograde transport vesicles from the Golgi apparatus. Aguilera-Romero A, et al. J Cell Biol, 2008 Feb 25. PMID 18283113, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cargo receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Erv25p
    NP_013701.1
    • Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1, Erp2p, and Emp24

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      246116..246751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182369.1 → NP_013701.1  TPA: Erv25p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013701.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZG2, P54837
      UniProtKB/TrEMBL
      A6ZM50, B3LLN9, B5VPB5, C7GLD0, C8ZEJ3, G2WK40, N1NYJ8
      Conserved Domains (1) summary
      pfam01105
      Location:20 → 206
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54837.1

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