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    ERV46 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851256, updated on 11-Sep-2024

    Summary

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    Official Symbol
    ERV46
    Primary source
    SGD:S000000040
    Locus tag
    YAL042W
    See related
    AllianceGenome:SGD:S000000040; FungiDB:YAL042W; VEuPathDB:YAL042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN9
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in COPII-coated ER to Golgi transport vesicle. Is integral component of Golgi membrane and integral component of endoplasmic reticulum membrane. Orthologous to human ERGIC3 (ERGIC and golgi 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (61316..62563)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene glycine decarboxylase subunit H Neighboring gene RNA-processing protein PTA1 Neighboring gene Rho family guanine nucleotide exchange factor CDC24 Neighboring gene cyclin CLN3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel membrane protein complex on the endoplasmic reticulum and early Golgi compartments in the yeast Saccharomyces cerevisiae. Cho JH, et al. Biosci Biotechnol Biochem, 2001 Oct. PMID 11758914
    2. Molecular dissection of the Erv41-Erv46 retrograde receptor reveals a conserved cysteine-rich region in Erv46 required for retrieval activity. Keiser KJ, et al. Mol Biol Cell, 2020 Feb 1. PMID 31825724, Free PMC Article
    3. The Erv41-Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteins. Shibuya A, et al. J Cell Biol, 2015 Jan 19. PMID 25583996, Free PMC Article
    4. The Erv41p-Erv46p complex: multiple export signals are required in trans for COPII-dependent transport from the ER. Otte S, et al. EMBO J, 2002 Nov 15. PMID 12426381, Free PMC Article
    5. Dual Independent Roles of the p24 Complex in Selectivity of Secretory Cargo Export from the Endoplasmic Reticulum. Lopez S, et al. Cells, 2020 May 22. PMID 32456004, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular dissection of the Erv41-Erv46 retrograde receptor reveals a conserved cysteine-rich region in Erv46 required for retrieval activity.
      Title: Molecular dissection of the Erv41-Erv46 retrograde receptor reveals a conserved cysteine-rich region in Erv46 required for retrieval activity.
    2. Binding of specific cargo by the Erv41-Erv46 complex in Golgi compartments identifies escaped endoplasmic reticulum (ER) resident proteins for retrieval to the ER.
      Title: The Erv41-Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Erv46p
    NP_009358.1
    • Protein localized to COPII-coated vesicles; forms a complex with Erv41p; involved in the membrane fusion stage of transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      61316..62563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178187.1 → NP_009358.1  TPA: Erv46p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009358.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPH4, P39727
      UniProtKB/TrEMBL
      A7A0C4, B3LUX8, B5VDH5, C7GPJ5, C8Z3E7, N1P8V1
      Conserved Domains (2) summary
      pfam07970
      Location:143 → 399
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:6 → 96
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39727.2

    Gene LinkOut

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