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    GDA1 guanosine diphosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856669, updated on 6-Oct-2024

    Summary

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    Official Symbol
    GDA1
    Official Full Name
    guanosine diphosphatase
    Primary source
    SGD:S000000768
    Locus tag
    YEL042W
    See related
    AllianceGenome:SGD:S000000768; FungiDB:YEL042W; VEuPathDB:YEL042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables guanosine-diphosphatase activity and uridine-diphosphatase activity. Involved in protein glycosylation. Located in Golgi apparatus. Orthologous to human ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive)) and ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GDA1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (73771..75327)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Ies6p Neighboring gene Gta1p Neighboring gene NADH/NAD(+) kinase Neighboring gene chitin transglycosylase UTR2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast model identifies ENTPD6 as a potential non-obstructive azoospermia pathogenic gene. Wang Q, et al. Sci Rep, 2015 Jul 8. PMID 26152596, Free PMC Article
    2. Identity between the PCPH proto-oncogene and the CD39L4 (ENTPD5) ectonucleoside triphosphate diphosphohydrolase gene. Páez JG, et al. Int J Oncol, 2001 Dec. PMID 11713596
    3. The UDPase activity of the Kluyveromyces lactis Golgi GDPase has a role in uridine nucleotide sugar transport into Golgi vesicles. Lopez-Avalos MD, et al. Glycobiology, 2001 May. PMID 11425802
    4. A role for the lumenal domain in Golgi localization of the Saccharomyces cerevisiae guanosine diphosphatase. Vowels JJ, et al. Mol Biol Cell, 1998 Jun. PMID 9614179, Free PMC Article
    5. Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae. Abeijon C, et al. J Cell Biol, 1993 Jul. PMID 8391537, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside diphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanosine diphosphatase
    NP_010872.1
    • Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen, converting GDP to GMP after mannose is transferred to substrates; null mutants are defective in sporulation and pre-meiotic S phase entry; orthologous to human ENTPD6, a meiosis-associated non-obstructive azoospermia (NOA) related gene identified in GWAS studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      73771..75327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178857.1 → NP_010872.1  TPA: guanosine diphosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010872.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLK7, P32621
      UniProtKB/TrEMBL
      A6ZQQ8, B3LRX4, B5VH93, C7GKE5, C8Z6V2, G2WCJ1, N1P5J2
      Conserved Domains (1) summary
      COG5371
      Location:1 → 518
      COG5371; Golgi nucleoside diphosphatase [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32621.1

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