HXT7 hexose transporter HXT7 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: HXT7
Gene description: hexose transporter HXT7
Primary source: FungiDB:YDR342C
Locus tag: YDR342C
See related: SGD:S000002750; AllianceGenome:SGD:S000002750; VEuPathDB:YDR342C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glucose transmembrane transporter activity and pentose transmembrane transporter activity. Involved in glucose transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HXT7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1154216..1155928, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

turnover of both Hxt3 and Hxt7 is dependent on the essential E3 ubiquitin ligase, Rsp5, indicating that the role of the Vid30c might be indirect of Hxt ubiquitylation
Title: Regulation of Hxt3 and Hxt7 turnover converges on the Vid30 complex and requires inactivation of the Ras/cAMP/PKA pathway in Saccharomyces cerevisiae.
The amino acid side chain length in transmembrane segment 5 of HXT7 is important for glucose affinity.
Title: Crucial effects of amino acid side chain length in transmembrane segment 5 on substrate affinity in yeast glucose transporter Hxt7.
Variation in the copy number of HXT6/HTX7 locus was observed in a survey of ~70 yeast strains.
Title: Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape.
Saccharomyces cerevisiae was engineered for enhanced arsenite accumulation by overexpression of transporters responsible for the influx of the contaminant. The transporter genes FPS1 and HXT7 were cloned under the control of the late-phase ADH2-promoter.
Title: Enhanced arsenic accumulation in Saccharomyces cerevisiae overexpressing transporters Fps1p or Hxt7p.
Asp(340) is situated at or close to a substrate recognition site and is a key residue determining high-affinity glucose transport by Hxt7
Title: Identification of a key residue determining substrate affinity in the yeast glucose transporter Hxt7: a two-dimensional comprehensive study.
promoter produces higher invertase activity at 139- and 30-fold of the basal activity in strains GN 3C.2 and W303-1, respectively
Title: Cell growth restoration and high level protein expression by the promoter of hexose transporter, HXT7, from Saccharomyces cerevisiae.
Saccharomyces galactose transporter system could be a highly effective xylose transporter. The information reported here should be of great importance for improving the Saccharomyces yeast transport of xylose.
Title: Characterization of the effectiveness of hexose transporters for transporting xylose during glucose and xylose co-fermentation by a recombinant Saccharomyces yeast.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables carbohydrate:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glucose transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mannose transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables pentose transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in hexose transmembrane transport	TAS Traceable Author Statement more info	PubMed
involved_in mannose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in pentose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hexose transporter HXT7

NP_010629.3

High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1154216..1155928 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180650.3 → NP_010629.3 TPA: hexose transporter HXT7 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010629.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSX3, P39004

UniProtKB/TrEMBL

A0A3G1C686, E9P9G7, G8FR13

Conserved Domains (1) summary

pfam00083
Location:68 → 528

Sugar_tr; Sugar (and other) transporter