U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PHA2 prephenate dehydratase PHA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855400, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PHA2
    Official Full Name
    prephenate dehydratase PHA2
    Primary source
    SGD:S000005260
    Locus tag
    YNL316C
    See related
    AllianceGenome:SGD:S000005260; FungiDB:YNL316C; VEuPathDB:YNL316C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables prephenate dehydratase activity. Involved in L-phenylalanine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PHA2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (42071..43075, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Hxt14p Neighboring gene cleavage polyadenylation factor subunit PFS2 Neighboring gene Atp11p Neighboring gene Dal82p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic mapping in Saccharomyces. Mortimer RK, et al. Genetics, 1966 Jan. PMID 5900603, Free PMC Article
    2. In vivo instability of chorismate causes substrate loss during fermentative production of aromatics. Winter G, et al. Yeast, 2014 Sep. PMID 24981409
    3. Sequencing analysis of a 24.7 kb fragment of yeast chromosome XIV identifies six known genes, a new member of the hexose transporter family and ten new open reading frames. Maftahi M, et al. Yeast, 1995 Sep 15. PMID 7502583
    4. Complementation of the pha2 yeast mutant suggests functional differences for arogenate dehydratases from Arabidopsis thaliana. Bross CD, et al. Plant Physiol Biochem, 2011 Aug. PMID 21388819
    5. Characterization of ATP11 and detection of the encoded protein in mitochondria of Saccharomyces cerevisiae. Ackerman SH, et al. J Biol Chem, 1992 Apr 15. PMID 1532796

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chorismate mutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prephenate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prephenate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prephenate dehydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-phenylalanine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-phenylalanine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-phenylalanine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    prephenate dehydratase PHA2
    NP_014083.2
    • Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      42071..43075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183154.1 → NP_014083.2  TPA: prephenate dehydratase PHA2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014083.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0M9, P32452
      UniProtKB/TrEMBL
      G2WLF3, N1NXB5
      Conserved Domains (1) summary
      COG0077
      Location:4 → 332
      PheA2; Prephenate dehydratase [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32452.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools