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    SMF2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856447, updated on 11-Sep-2024

    Summary

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    Official Symbol
    SMF2
    Primary source
    SGD:S000001092
    Locus tag
    YHR050W
    See related
    AllianceGenome:SGD:S000001092; FungiDB:YHR050W; VEuPathDB:YHR050W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables inorganic cation transmembrane transporter activity. Involved in cellular transition metal ion homeostasis and transition metal ion transport. Located in late endosome and trans-Golgi network. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (207654..209303)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Yhk8p Neighboring gene putative serine hydrolase Neighboring gene uncharacterized protein Neighboring gene cytochrome c oxidase subunit VI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast SMF1 mediates H(+)-coupled iron uptake with concomitant uncoupled cation currents. Chen XZ, et al. J Biol Chem, 1999 Dec 3. PMID 10574989
    2. Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. Bolden S Jr, et al. Eur J Med Chem, 2013. PMID 24141203, Free PMC Article
    3. The Saccharomyces cerevisiae high affinity phosphate transporter encoded by PHO84 also functions in manganese homeostasis. Jensen LT, et al. J Biol Chem, 2003 Oct 24. PMID 12923174
    4. Overexpression, purification, and site-directed spin labeling of the Nramp metal transporter from Mycobacterium leprae. Reeve I, et al. Proc Natl Acad Sci U S A, 2002 Jun 25. PMID 12077319, Free PMC Article
    5. Manganese superoxide dismutase in Saccharomyces cerevisiae acquires its metal co-factor through a pathway involving the Nramp metal transporter, Smf2p. Luk EE, et al. J Biol Chem, 2001 Dec 14. PMID 11602606

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cadmium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cobalt ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular cobalt ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular manganese ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular manganese ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in manganese ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in manganese ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in manganese ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    divalent metal ion transporter SMF2
    NP_011917.1
    • Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      207654..209303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179180.1 → NP_011917.1  TPA: divalent metal ion transporter SMF2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011917.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKZ8, P38778
      UniProtKB/TrEMBL
      A6ZSV7, B5VJY1, G2WFC3, N1P576
      Conserved Domains (1) summary
      TIGR01197
      Location:55 → 458
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38778.1

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