U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SRN2 ESCRT-I subunit protein SRN2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850810, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SRN2
    Official Full Name
    ESCRT-I subunit protein SRN2
    Primary source
    SGD:S000004109
    Locus tag
    YLR119W
    See related
    AllianceGenome:SGD:S000004109; FungiDB:YLR119W; VEuPathDB:YLR119W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SRN10; VPL16; VPS37
    Summary
    Involved in ATP export; protein targeting to membrane; and protein targeting to vacuole. Located in endosome. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SRN2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (385534..386175)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Clf1p Neighboring gene palmitoyl-(protein) hydrolase Neighboring gene aspartyl protease Neighboring gene aspartyl protease

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Isolation of an extragenic suppressor of the rna1-1 mutation in Saccharomyces cerevisiae. Hong SJ, et al. Mol Gen Genet, 1998 Sep. PMID 9790597
    2. Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12. Curtiss M, et al. Mol Biol Cell, 2007 Feb. PMID 17135292, Free PMC Article
    3. ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes. Teo H, et al. Cell, 2006 Apr 7. PMID 16615893
    4. Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins. Teo H, et al. J Biol Chem, 2004 Jul 2. PMID 15044434
    5. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Katzmann DJ, et al. Cell, 2001 Jul 27. PMID 11511343

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome transport via multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of protein localization to vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ESCRT I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ESCRT I complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ESCRT-I subunit protein SRN2
    NP_013220.1
    • Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      385534..386175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182006.1 → NP_013220.1  TPA: ESCRT-I subunit protein SRN2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013220.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYB7, Q02806, Q99176
      UniProtKB/TrEMBL
      A7A121, N1P168
      Conserved Domains (1) summary
      pfam07200
      Location:57 → 202
      Mod_r; Modifier of rudimentary (Mod(r)) protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99176.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous