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    APQ12 Apq12p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854771, updated on 29-Jun-2024

    Summary

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    Gene symbol
    APQ12
    Gene description
    Apq12p
    Primary source
    FungiDB:YIL040W
    Locus tag
    YIL040W
    See related
    SGD:S000001302; AllianceGenome:SGD:S000001302; VEuPathDB:YIL040W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in lipid homeostasis and nuclear envelope organization. Located in endoplasmic reticulum and nuclear envelope. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See APQ12 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (277723..278139)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene protein kinase PKP1 Neighboring gene Gvp36p Neighboring gene Ted1p Neighboring gene CCR4-NOT core subunit NOT3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast Apq12 protein affects nucleocytoplasmic mRNA transport. Baker KE, et al. RNA, 2004 Sep. PMID 15273328, Free PMC Article
    2. A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis. Zhang W, et al. Open Biol, 2021 Nov. PMID 34814743, Free PMC Article
    3. Genome-wide mRNA surveillance is coupled to mRNA export. Hieronymus H, et al. Genes Dev, 2004 Nov 1. PMID 15489286, Free PMC Article
    4. Direct binding of ESCRT protein Chm7 to phosphatidic acid-rich membranes at nuclear envelope herniations. Thaller DJ, et al. J Cell Biol, 2021 Mar 1. PMID 33464310, Free PMC Article
    5. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Frost A, et al. Cell, 2012 Jun 8. PMID 22682253, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A short perinuclear amphipathic alpha-helix in Apq12 promotes nuclear pore complex biogenesis.
      Title: A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis.
    2. Results report that Apq12 is required for efficient nuclear pore complex biogenesis in Saccharomyces cerevisiae.
      Title: The yeast integral membrane protein Apq12 potentially links membrane dynamics to assembly of nuclear pore complexes.
    3. Apq12 is found to interact with the kinetochore, revealing a novel relationship between nucleocytoplasmic transport and chromosome stability.
      Title: Genome-wide synthetic lethal screens identify an interaction between the nuclear envelope protein, Apq12p, and the kinetochore in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear envelope organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Apq12p
    NP_012224.1
    • Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      277723..278139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179390.1 → NP_012224.1  TPA: Apq12p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012224.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVP2, P40532
      UniProtKB/TrEMBL
      A0A6A5PZZ5, A6ZVM9, B3LTP6, C7GVW8, C8ZAK6, G2WGA6, N1P952
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40532.1

    Gene LinkOut

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