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    IMA5 oligo-1,6-glucosidase IMA5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853214, updated on 17-May-2024

    Summary

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    Gene symbol
    IMA5
    Gene description
    oligo-1,6-glucosidase IMA5
    Primary source
    FungiDB:YJL216C
    Locus tag
    YJL216C
    See related
    SGD:S000003752; AllianceGenome:SGD:S000003752; VEuPathDB:YJL216C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables oligo-1,6-glucosidase activity. Involved in disaccharide catabolic process. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to several human genes including SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See IMA5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (24341..26086, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene acetyltransferase Neighboring gene Ree1p Neighboring gene hexose transporter HXT8 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extracellular maltotriose hydrolysis by Saccharomyces cerevisiae cells lacking the AGT1 permease. Alves SL Jr, et al. Lett Appl Microbiol, 2018 Oct. PMID 29992585
    2. Similarities and differences in the biochemical and enzymological properties of the four isomaltases from Saccharomyces cerevisiae. Deng X, et al. FEBS Open Bio, 2014. PMID 24649402, Free PMC Article
    3. Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X. Vandenbol M, et al. Yeast, 1994 Dec. PMID 7725802
    4. Iterative screening methodology enables isolation of strains with improved properties for a FACS-based screen and increased L-DOPA production. Savitskaya J, et al. Sci Rep, 2019 Apr 9. PMID 30967567, Free PMC Article
    5. Identification of a Saccharomyces cerevisiae glucosidase that hydrolyzes flavonoid glucosides. Schmidt S, et al. Appl Environ Microbiol, 2011 Mar. PMID 21216897, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucan 1,4-alpha-maltotriohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables maltose alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oligo-1,6-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oligo-1,6-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oligo-1,6-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligo-1,6-glucosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sucrose alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in disaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in disaccharide catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maltose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maltose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sucrose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    oligo-1,6-glucosidase IMA5
    NP_012319.1
    • Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; most distant member of the IMA isomaltase family, but with similar catalytic properties as Ima1p and Ima2p; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose; can cleave alpha-1,3 linkage of nigerose and turanose and alpha-1,5 linkage of leucrose and is very sensitive to temperature in vitro

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      24341..26086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181649.1 → NP_012319.1  TPA: oligo-1,6-glucosidase IMA5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012319.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVY0, P40884
      UniProtKB/TrEMBL
      A0A8H4F975, E1AFZ0, N1P1D7
      Conserved Domains (2) summary
      cd11333
      Location:11 → 498
      AmyAc_SI_OligoGlu_DGase; Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins
      cl02706
      Location:509 → 548
      Malt_amylase_C; Maltogenic Amylase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40884.1

    Gene LinkOut

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