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    YOX1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854981, updated on 11-Sep-2024

    Summary

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    Official Symbol
    YOX1
    Primary source
    SGD:S000004489
    Locus tag
    YML027W
    See related
    AllianceGenome:SGD:S000004489; FungiDB:YML027W; VEuPathDB:YML027W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription involved in G1/S transition of mitotic cell cycle. Located in chromatin and nucleus. Human ortholog(s) of this gene implicated in several diseases, including X-linked lissencephaly 2; cleft lip; eye disease (multiple); intellectual disability (multiple); and tooth disease (multiple). Orthologous to several human genes including ALX4 (ALX homeobox 4); BARHL1 (BarH like homeobox 1); and BARHL2 (BarH like homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (221406..222563)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Usa1p Neighboring gene thioredoxin peroxidase TSA1 Neighboring gene ribosomal 40S subunit protein S18B Neighboring gene mitochondrial 54S ribosomal protein YmL6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vitro binding to the leucine tRNA gene identifies a novel yeast homeobox gene. Kaufmann E. Chromosoma, 1993 Feb. PMID 8096171
    2. Cdk1 promotes kinetochore bi-orientation and regulates Cdc20 expression during recovery from spindle checkpoint arrest. Liang H, et al. EMBO J, 2012 Jan 18. PMID 22056777, Free PMC Article
    3. Conserved homeodomain proteins interact with MADS box protein Mcm1 to restrict ECB-dependent transcription to the M/G1 phase of the cell cycle. Pramila T, et al. Genes Dev, 2002 Dec 1. PMID 12464633, Free PMC Article
    4. YHP1 encodes a new homeoprotein that binds to the IME1 promoter in Saccharomyces cerevisiae. Kunoh T, et al. Yeast, 2000 Mar 30. PMID 10705372
    5. A competitive transcription factor binding mechanism determines the timing of late cell cycle-dependent gene expression. Darieva Z, et al. Mol Cell, 2010 Apr 9. PMID 20385087, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sequence-specific DNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Yox1p
    NP_013685.1
    • Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      221406..222563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182385.1 → NP_013685.1  TPA: Yox1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013685.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZE7, P34161
      UniProtKB/TrEMBL
      A6ZM35, B3LLM5, B5VP99, C7GT57, C8ZEH7, G2WK25, N1P6B4
      Conserved Domains (1) summary
      COG5576
      Location:126 → 267
      COG5576; Homeodomain-containing transcription factor [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34161.2

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