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    URN1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856275, updated on 11-Sep-2024

    Summary

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    Official Symbol
    URN1
    Primary source
    SGD:S000006356
    Locus tag
    YPR152C
    See related
    AllianceGenome:SGD:S000006356; FungiDB:YPR152C; VEuPathDB:YPR152C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleus. Part of prespliceosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (832061..833458, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Nce102p Neighboring gene Sue1p Neighboring gene May24p Neighboring gene Pin3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A single cysteine post-translational oxidation suffices to compromise globular proteins kinetic stability and promote amyloid formation. Marinelli P, et al. Redox Biol, 2018 Apr. PMID 29132128, Free PMC Article
    2. Solution structure of the yeast URN1 splicing factor FF domain: comparative analysis of charge distributions in FF domain structures-FFs and SURPs, two domains with a similar fold. Bonet R, et al. Proteins, 2008 Dec. PMID 18536009
    3. The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Fabrizio P, et al. Mol Cell, 2009 Nov 25. PMID 19941820
    4. Genetic and biochemical characterization of the yeast spo12 protein. Grether ME, et al. Mol Biol Cell, 1999 Nov. PMID 10564265, Free PMC Article
    5. Rapid screening of yeast mutants with reporters identifies new splicing phenotypes. Dreumont N, et al. FEBS J, 2013 Jun. PMID 23560879

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The irreversible oxidation of a single free Cys suffices to severely perturb the folding energy landscape of a stable globular protein, compromise its kinetic stability, and lead to the formation of amyloids under physiological conditions.
      Title: A single cysteine post-translational oxidation suffices to compromise globular proteins kinetic stability and promote amyloid formation.
    2. The solution structure reveals that the FF domain of URN1 adopts the classical FF fold, with a distinctive negatively charged patch on its surface.
      Title: Solution structure of the yeast URN1 splicing factor FF domain: comparative analysis of charge distributions in FF domain structures-FFs and SURPs, two domains with a similar fold.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Urn1p
    NP_015478.1
    • hypothetical protein containing WW and FF domains; overexpression causes accumulation of cells in G1 phase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      832061..833458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184249.1 → NP_015478.1  TPA: Urn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015478.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4E8, Q06525
      UniProtKB/TrEMBL
      B5VTT8, C8ZJH6, J7FIN9, N1NXU4
      Conserved Domains (3) summary
      COG5104
      Location:2 → 88
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:5 → 30
      WW; WW domain
      pfam01846
      Location:219 → 263
      FF; FF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06525.1

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