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    NPT1 nicotinate phosphoribosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854384, updated on 4-Aug-2024

    Summary

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    Gene symbol
    NPT1
    Gene description
    nicotinate phosphoribosyltransferase
    Primary source
    FungiDB:YOR209C
    Locus tag
    YOR209C
    See related
    SGD:S000005735; AllianceGenome:SGD:S000005735; VEuPathDB:YOR209C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables nicotinate phosphoribosyltransferase activity. Involved in nicotinate nucleotide salvage; rDNA heterochromatin assembly; and subtelomeric heterochromatin assembly. Located in nucleus. Orthologous to human NAPRT (nicotinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NPT1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (736437..737726, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase III core subunit RET1 Neighboring gene tyrosine protein phosphatase PTP2 Neighboring gene DNA-directed RNA polymerase core subunit RPB10 Neighboring gene dynamin-related GTPase MGM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. Chappie JS, et al. Structure, 2005 Sep. PMID 16154095
    2. Conversion of a cosubstrate to an inhibitor: phosphorylation mutants of nicotinic acid phosphoribosyltransferase. Rajavel M, et al. Biochemistry, 1998 Mar 24. PMID 9521740
    3. Kinetic analysis of nicotinate phosphoribosyltransferase from yeast using high pressure liquid chromatography. Hanna LS, et al. J Biol Chem, 1983 Aug 25. PMID 6224784
    4. Quantitation of NAD+ biosynthesis from the salvage pathway in Saccharomyces cerevisiae. Sporty J, et al. Yeast, 2009 Jul. PMID 19399913, Free PMC Article
    5. Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases. Rössl A, et al. Genetics, 2016 Oct. PMID 27527516, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structure of NPT1 at 1.75 A resolution was reported.
      Title: The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinate phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nicotinate nucleotide salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nicotinate phosphoribosyltransferase
    NP_014852.1
    • Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      736437..737726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183628.1 → NP_014852.1  TPA: nicotinate phosphoribosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2R5, P39683, Q08626
      UniProtKB/TrEMBL
      B5VS92, C7GWH3, C8ZGW5, N1NWS2
      Conserved Domains (1) summary
      TIGR01514
      Location:5 → 416
      NAPRTase; nicotinate phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39683.3

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