Csnk1a1 casein kinase 1, alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csnk1a1provided by MGI
Official Full Name: casein kinase 1, alpha 1provided by MGI
Primary source: MGI:MGI:1934950
See related: Ensembl:ENSMUSG00000024576 AllianceGenome:MGI:1934950
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CK1a; Csnk1a; 2610208K14Rik; 4632404G05Rik; 5430427P18Rik
Summary: Enables protein serine/threonine kinase activity. Involved in negative regulation of NLRP3 inflammasome complex assembly and protein phosphorylation. Acts upstream of or within cell morphogenesis. Located in ciliary basal body and spindle. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; endocrine gland; metanephros; retina nuclear layer; and thymus primordium. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in CNS E14 (RPKM 23.9), bladder adult (RPKM 23.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 34.62 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (61687307..61723391)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (61554236..61590320)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Casein kinase 1alpha mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.
Title: Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.
Exploring the role of casein kinase 1alpha splice variants across cancer cell lines.
Title: Exploring the role of casein kinase 1α splice variants across cancer cell lines.
CK1alpha deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3beta pathway and inhibiting Foxa2 expression through p53 pathwaydagger.
Title: CK1α deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3β pathway and inhibiting Foxa2 expression through p53 pathway†.
Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation.
Title: Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation.
CSNK1A1/CK1alpha suppresses autoimmunity by restraining the CGAS-STING1 signaling.
Title: CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.
Casein Kinase 1alpha Regulates Testosterone Synthesis and Testis Development in Adult Mice.
Title: Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.
Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1alpha S-glutathionylation during posterior capsular opacification.
Title: Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1α S-glutathionylation during posterior capsular opacification.
Casein Kinase 1alpha as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.
Title: Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.
Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.
Title: Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.
Class III beta-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.
Title: Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Csnk1a1 (e-PCR), detects polymorphism
- UniSTS:532269

BE111197 (e-PCR)
- UniSTS:245625

AI314760 (e-PCR)
- UniSTS:181133

X90945 (e-PCR)
- UniSTS:125883

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to nutrient	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intermediate filament cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	ISS Inferred from Sequence or Structural Similarity more info
part_of beta-catenin destruction complex	NAS Non-traceable Author Statement more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	TAS Traceable Author Statement more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
colocalizes_with keratin filament	ISO Inferred from Sequence Orthology more info
colocalizes_with keratin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
part_of mRNA cleavage and polyadenylation specificity factor complex	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage and polyadenylation specificity factor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: casein kinase I isoform alpha; casein kinase I

Names: CK1; CKI-alpha; casein kinase I-alpha

NP_001344427.1

EC 2.7.11.1

NP_001344428.1

EC 2.7.11.1

NP_001344429.1

EC 2.7.11.1

NP_666199.1

EC 2.7.11.1

XP_006526446.1

EC 2.7.11.1

XP_006526449.1

EC 2.7.11.1

XP_011245350.1

EC 2.7.11.1

XP_030106505.1

EC 2.7.11.1

XP_030106506.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357498.1 → NP_001344427.1 casein kinase I isoform alpha isoform 2

Status: VALIDATED

Source sequence(s)

AC153155, AI853067

Consensus CDS

CCDS89252.1

UniProtKB/TrEMBL

E9Q3W1, Q3U772

Related

ENSMUSP00000127265.2, ENSMUST00000170862.8

Conserved Domains (1) summary

cd14128
Location:16 → 309

STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
NM_001357499.1 → NP_001344428.1 casein kinase I isoform alpha isoform 3

Status: VALIDATED

Source sequence(s)

AC153155, AI853067

Consensus CDS

CCDS89251.1

UniProtKB/TrEMBL

E9Q2U6, Q3U844

Related

ENSMUSP00000127463.2, ENSMUST00000167187.8

Conserved Domains (1) summary

cd14128
Location:16 → 309

STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
NM_001357500.1 → NP_001344429.1 casein kinase I isoform alpha isoform 4

Status: VALIDATED

Source sequence(s)

AC153155, AI853067

Consensus CDS

CCDS89254.1

UniProtKB/Swiss-Prot

Q3UIL0, Q64506, Q80XI2, Q8BK63, Q99LY3

UniProtKB/TrEMBL

Q3U772

Related

ENSMUSP00000132083.2, ENSMUST00000165721.8

Conserved Domains (1) summary

cd14128
Location:16 → 281

STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
NM_146087.3 → NP_666199.1 casein kinase I isoform alpha isoform 1

See identical proteins and their annotated locations for NP_666199.1

Status: VALIDATED

Source sequence(s)

AC153155, AI853067, AK076070, AK146873, BY065893

Consensus CDS

CCDS37838.1

UniProtKB/TrEMBL

Q3U844, Q6PJ87

Related

ENSMUSP00000128871.2, ENSMUST00000165123.8

Conserved Domains (1) summary

cd14128
Location:16 → 281

STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

61687307..61723391

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247048.3 → XP_011245350.1 casein kinase I isoform X1

UniProtKB/TrEMBL

Q3U772

Conserved Domains (1) summary

cd14128
Location:16 → 309

STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
XM_006526383.4 → XP_006526446.1 casein kinase I isoform X2

UniProtKB/TrEMBL

Q3U772

Conserved Domains (1) summary

cd14128
Location:16 → 309

STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
XM_006526386.4 → XP_006526449.1 casein kinase I isoform X3

UniProtKB/TrEMBL

Q3U844

Conserved Domains (1) summary

cd14128
Location:16 → 309

STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
XM_030250645.1 → XP_030106505.1 casein kinase I isoform X4

UniProtKB/TrEMBL

Q3U772

Related

ENSMUSP00000127144.2, ENSMUST00000163205.8

Conserved Domains (1) summary

cd14128
Location:16 → 281

STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
XM_030250646.1 → XP_030106506.1 casein kinase I isoform X5

UniProtKB/TrEMBL

H7BXB1, Q3U844

Related

ENSMUSP00000110901.3, ENSMUST00000115246.9

Conserved Domains (1) summary

cd14128
Location:16 → 281

STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha