PTX3 pentraxin 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTX3provided by HGNC
Official Full Name: pentraxin 3provided by HGNC
Primary source: HGNC:HGNC:9692
See related: Ensembl:ENSG00000163661 MIM:602492; AllianceGenome:HGNC:9692
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TSG-14; TNFAIP5
Summary: This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]
Expression: Biased expression in bone marrow (RPKM 32.2), appendix (RPKM 24.8) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q25.32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (157436850..157443633)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (160211418..160218201)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (157154639..157161422)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis.
Title: NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis.
Functional variants of the pentraxin 3 gene are associated with the metastasis and progression of prostate cancer.
Title: Functional variants of the pentraxin 3 gene are associated with the metastasis and progression of prostate cancer.
EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells.
Title: EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells.
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease.
Title: Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease.
The role of pentraxin 3 and oxidative status in the prognosis of multiple myeloma.
Title: The role of pentraxin 3 and oxidative status in the prognosis of multiple myeloma.
Pentraxin 3 exacerbates psoriasiform dermatitis through regulation of macrophage polarization.
Title: Pentraxin 3 exacerbates psoriasiform dermatitis through regulation of macrophage polarization.
Bone morphogenetic protein 6 induces downregulation of pentraxin 3 expression in human granulosa lutein cells in women with polycystic ovary syndrome.
Title: Bone morphogenetic protein 6 induces downregulation of pentraxin 3 expression in human granulosa lutein cells in women with polycystic ovary syndrome.
Long pentraxin 3 and vitamin D receptor mRNA expression pattern of cumulus granulosa cells isolated from PCOS oocytes at different stages of nuclear maturation.
Title: Long pentraxin 3 and vitamin D receptor mRNA expression pattern of cumulus granulosa cells isolated from PCOS oocytes at different stages of nuclear maturation.
Serum Pentaxin 3 (PTX3) Promotes NLRP3 Inflammasome and Pyroptosis in Patients with Up-Regulated Myasthenia Gravis.
Title: Serum Pentaxin 3 (PTX3) Promotes NLRP3 Inflammasome and Pyroptosis in Patients with Up-Regulated Myasthenia Gravis.
Role of long pentraxin PTX3 in cancer.
Title: Role of long pentraxin PTX3 in cancer.

Submit: New GeneRIF Correction See all GeneRIFs (452)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PTX3_470 (e-PCR)
- UniSTS:280948

WI-7070 (e-PCR)
- UniSTS:75145

GDB:252088 (e-PCR)
- UniSTS:156325

SHGC-77488 (e-PCR)
- UniSTS:2537

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables (1->3)-beta-D-glucan binding	IEA Inferred from Electronic Annotation more info
enables complement component C1q complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C1q complex binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables virion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation by host of viral exo-alpha-sialidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation by host of viral glycoprotein metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation by host of viral process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of exo-alpha-sialidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glycoprotein metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in opsonization	IEA Inferred from Electronic Annotation more info
involved_in ovarian cumulus expansion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in response to yeast	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in specific granule lumen	TAS Traceable Author Statement more info
located_in tertiary granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: pentraxin-related protein PTX3

Names: TNF alpha-induced protein 5; long pentraxin 3; tumor necrosis factor alpha-induced protein 5; tumor necrosis factor-inducible gene 14 protein; tumor necrosis factor-inducible protein TSG-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051000.1 RefSeqGene

Range

5060..11843

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002852.4 → NP_002843.2 pentraxin-related protein PTX3 precursor

See identical proteins and their annotated locations for NP_002843.2

Status: REVIEWED

Source sequence(s)

AC020630, BC039733, BQ010272, DA716533

Consensus CDS

CCDS3180.1

UniProtKB/Swiss-Prot

B2R6T6, P26022, Q38M82

Related

ENSP00000295927.3, ENST00000295927.4

Conserved Domains (2) summary

smart00159
Location:175 → 381

PTX; Pentraxin / C-reactive protein / pentaxin family

cl23844
Location:81 → 167

Ble; Predicted trehalose synthase [Carbohydrate transport and metabolism]