rlbp1a retinaldehyde binding protein 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rlbp1aprovided by ZNC
Official Full Name: retinaldehyde binding protein 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1662
See related: Ensembl:ENSDARG00000012504 AllianceGenome:ZFIN:ZDB-GENE-040426-1662
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rlbp1l; CRALBPa; zgc:73076
Summary: Predicted to enable phosphatidylinositol bisphosphate binding activity. Acts upstream of or within optokinetic behavior and photoreceptor cell maintenance. Is expressed in brain; optic vesicle; and visual system. Used to study Bothnia retinal dystrophy; Newfoundland cone-rod dystrophy; fundus albipunctatus; and retinitis pigmentosa. Human ortholog(s) of this gene implicated in Bothnia retinal dystrophy; Newfoundland cone-rod dystrophy; fundus albipunctatus; night blindness; and retinitis pigmentosa. Orthologous to human RLBP1 (retinaldehyde binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (13867721..13884508, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (13620944..13638474, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The downregulation of HSP90-controlled CRALBP expression is associated with age-related vision attenuation.
Title: The downregulation of HSP90-controlled CRALBP expression is associated with age-related vision attenuation.
Cralbp a expression in retinal pigment epithelial cells is essential for cone vision and provides evidence that both the canonical and the alternative visual cycle depend on the same type of retinoid-binding protein.
Title: Subfunctionalization of a retinoid-binding protein provides evidence for two parallel visual cycles in the cone-dominant zebrafish retina.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within optokinetic behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: retinaldehyde-binding protein 1a

Names: cralbpb; rlbp1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.