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    cdc42ep3 CDC42 effector protein (Rho GTPase binding) 3 [ Danio rerio (zebrafish) ]

    Gene ID: 447829, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cdc42ep3provided by ZNC
    Official Full Name
    CDC42 effector protein (Rho GTPase binding) 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040912-89
    See related
    Ensembl:ENSDARG00000052783 AllianceGenome:ZFIN:ZDB-GENE-040912-89
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92806
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of cellular component biogenesis; and regulation of cell shape. Predicted to be located in endomembrane system. Predicted to be active in cytoplasm; cytoskeleton; and plasma membrane. Is expressed in epidermis; muscle pioneer; pectoral fin musculature; peripheral olfactory organ; and tail bud. Orthologous to human CDC42EP3 (CDC42 effector protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cdc42ep3 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (42124565..42143648)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (41997652..42017587)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103912033 Neighboring gene regulator of microtubule dynamics 2 Neighboring gene opsin 3 Neighboring gene kynurenine 3-monooxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. Quach HN, et al. G3 (Bethesda), 2015 Apr 2. PMID 25840430, Free PMC Article
    2. Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1. Kimelman D, et al. Elife, 2017 Dec 28. PMID 29283341, Free PMC Article
    3. Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Lee HJ, et al. Genome Biol, 2020 Feb 27. PMID 32106888, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of pseudopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cdc42 effector protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004568.2 → NP_001004568.1  cdc42 effector protein 3

      See identical proteins and their annotated locations for NP_001004568.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081677
      UniProtKB/TrEMBL
      A0A8M2BGT0, Q66HU1
      Related
      ENSDARP00000069193.4, ENSDART00000074707.5
      Conserved Domains (2) summary
      pfam14957
      Location:271 → 298
      BORG_CEP; Cdc42 effector
      cl00113
      Location:30 → 70
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      42124565..42143648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169526.5 → XP_005169583.1  cdc42 effector protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005169583.1

      UniProtKB/TrEMBL
      A0A8M2BGT0, Q66HU1
      Conserved Domains (2) summary
      pfam14957
      Location:271 → 298
      BORG_CEP; Cdc42 effector
      cl00113
      Location:30 → 70
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    Nucleotide Protein
    Heading Accession and Version

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