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    fsta follistatin a [ Danio rerio (zebrafish) ]

    Gene ID: 100004116, updated on 2-Nov-2024

    Summary

    Official Symbol
    fstaprovided by ZNC
    Official Full Name
    follistatin aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990714-11
    See related
    Ensembl:ENSDARG00000052846 AllianceGenome:ZFIN:ZDB-GENE-990714-11
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fs; fst; fst1; cb446; fd07h10; wu:fd07h10
    Summary
    Predicted to enable activin binding activity. Acts upstream of or within determination of dorsal identity; embryonic organ morphogenesis; and midbrain development. Predicted to be active in extracellular space. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural rod; and neural tube. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See fsta in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (40504910..40510399, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (39904757..39910273, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 15a Neighboring gene heat shock protein, alpha-crystallin-related, b3 Neighboring gene NADH:ubiquinone oxidoreductase subunit S4 Neighboring gene uncharacterized LOC137490155 Neighboring gene uncharacterized LOC137495615 Neighboring gene uncharacterized LOC103911097

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC100822, MGC173526

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables activin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    follistatin-A
    Names
    activin-binding protein
    follistatin-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131037.3NP_571112.3  follistatin-A precursor

      See identical proteins and their annotated locations for NP_571112.3

      Status: VALIDATED

      Source sequence(s)
      BX537294
      UniProtKB/Swiss-Prot
      A5PMK3, A7MC96, Q6DC45, Q9YHV4
      Related
      ENSDARP00000051064.4, ENSDART00000051065.6
      Conserved Domains (2) summary
      smart00280
      Location:120167
      KAZAL; Kazal type serine protease inhibitors
      cd00104
      Location:199242
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      40504910..40510399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165257.5XP_005165314.1  follistatin-A isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCI8
      Related
      ENSDARP00000122591.1, ENSDART00000146237.3
      Conserved Domains (2) summary
      smart00280
      Location:120167
      KAZAL; Kazal type serine protease inhibitors
      cd00104
      Location:199242
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    2. XM_009301618.4XP_009299893.1  follistatin-A isoform X2

      UniProtKB/TrEMBL
      A0A8M3AZS1
      Conserved Domains (2) summary
      smart00280
      Location:120167
      KAZAL; Kazal type serine protease inhibitors
      cd00104
      Location:199242
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394601.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      329969..335458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)