tat tyrosine aminotransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tatprovided by ZNC
Official Full Name: tyrosine aminotransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1144
See related: Ensembl:ENSDARG00000069630 AllianceGenome:ZFIN:ZDB-GENE-030131-1144
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb60g09; zgc:154059; si:ch211-238a12.1
Summary: Predicted to enable L-tyrosine-2-oxoglutarate transaminase activity. Predicted to be involved in L-phenylalanine catabolic process and tyrosine catabolic process. Predicted to act upstream of or within aromatic amino acid metabolic process and biosynthetic process. Is expressed in liver. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type II. Orthologous to human TAT (tyrosine aminotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (13162727..13179516)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (13194010..13210998)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb60g09.x1 (e-PCR)
- UniSTS:203372

fd48b06.y1 (e-PCR)
- UniSTS:195509

AI497495 (e-PCR)
- UniSTS:206335

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-tyrosine-2-oxoglutarate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-tyrosine-2-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within amino acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tyrosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tyrosine catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: tyrosine aminotransferase

NP_001071022.2

EC 2.6.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.