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    cep43 centrosomal protein 43 [ Danio rerio (zebrafish) ]

    Gene ID: 415215, updated on 24-Nov-2024

    Summary

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    Official Symbol
    cep43provided by ZNC
    Official Full Name
    centrosomal protein 43provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090417-1
    See related
    Ensembl:ENSDARG00000003058 AllianceGenome:ZFIN:ZDB-GENE-090417-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ccr6a; fgfr1op; zgc:86782
    Summary
    Predicted to enable calcium ion binding activity. Predicted to act upstream of or within cell projection organization and microtubule anchoring. Predicted to be located in cell projection and microtubule organizing center. Predicted to be active in centrosome. Orthologous to human CEP43 (centrosomal protein 43). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cep43 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (30579000..30610172)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (30676082..30707291)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene ribonuclease H1 Neighboring gene myelin transcription factor 1-like, a Neighboring gene chemokine (C-C motif) receptor 6a Neighboring gene acyl-Coenzyme A binding domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. Lv Y, et al. J Biol Chem, 2024 Mar. PMID 38382674, Free PMC Article
    2. Defining the origins and evolution of the chemokine/chemokine receptor system. DeVries ME, et al. J Immunol, 2006 Jan 1. PMID 16365434
    3. Time point-based integrative analyses of deep-transcriptome identify four signal pathways in blastemal regeneration of zebrafish lower jaw. Zhang H, et al. Stem Cells, 2015 Mar. PMID 25420467
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microtubule anchoring IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein 43
    Names
    FGFR1 oncogene partner

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002125.1 → NP_001002125.1  centrosomal protein 43

      See identical proteins and their annotated locations for NP_001002125.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071450
      UniProtKB/TrEMBL
      A0A8M1MZX4, Q6IQF6
      Related
      ENSDARP00000011529.7, ENSDART00000010494.10
      Conserved Domains (2) summary
      pfam09398
      Location:48 → 128
      FOP_dimer; FOP N terminal dimerization domain
      pfam13499
      Location:161 → 225
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      30579000..30610172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468390.2 → XP_021324065.1  centrosomal protein 43 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PSK8
      Conserved Domains (1) summary
      pfam09398
      Location:48 → 128
      FOP_dimer; FOP N terminal dimerisation domain

    2. XM_021468391.2 → XP_021324066.1  centrosomal protein 43 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PP81
      Conserved Domains (1) summary
      pfam09398
      Location:48 → 128
      FOP_dimer; FOP N terminal dimerisation domain

    3. XM_005160662.5 → XP_005160719.1  centrosomal protein 43 isoform X4

      UniProtKB/TrEMBL
      A0A8M2B7J0
      Conserved Domains (2) summary
      pfam09398
      Location:48 → 128
      FOP_dimer; FOP N terminal dimerization domain
      pfam13499
      Location:161 → 225
      EF-hand_7; EF-hand domain pair

    4. XM_068215409.1 → XP_068071510.1  centrosomal protein 43 isoform X5

    5. XM_005160663.5 → XP_005160720.1  centrosomal protein 43 isoform X7

      UniProtKB/TrEMBL
      A0A8M2B7I9
      Conserved Domains (3) summary
      pfam09398
      Location:48 → 128
      FOP_dimer; FOP N terminal dimerization domain
      pfam13499
      Location:161 → 225
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:160 → 226
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    6. XM_068215410.1 → XP_068071511.1  centrosomal protein 43 isoform X8

    7. XM_021468393.2 → XP_021324068.1  centrosomal protein 43 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PBN5
      Conserved Domains (1) summary
      pfam09398
      Location:48 → 128
      FOP_dimer; FOP N terminal dimerisation domain

    8. XM_017352461.3 → XP_017207950.1  centrosomal protein 43 isoform X10

      UniProtKB/TrEMBL
      A0A8M6YUS2

    9. XM_021468392.2 → XP_021324067.1  centrosomal protein 43 isoform X3

      UniProtKB/TrEMBL
      A0A8M9P2I3
      Conserved Domains (1) summary
      pfam09398
      Location:48 → 128
      FOP_dimer; FOP N terminal dimerisation domain

    10. XM_005160664.5 → XP_005160721.1  centrosomal protein 43 isoform X9

      UniProtKB/TrEMBL
      A0A0R4IW74, A0A8M2B7S5
      Related
      ENSDARP00000139051.1, ENSDART00000159485.2
      Conserved Domains (3) summary
      pfam09398
      Location:48 → 128
      FOP_dimer; FOP N terminal dimerization domain
      pfam13499
      Location:161 → 225
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:160 → 226
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    11. XM_068215412.1 → XP_068071513.1  centrosomal protein 43 isoform X11

    Nucleotide Protein
    Heading Accession and Version

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