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    pdia4 protein disulfide isomerase family A, member 4 [ Danio rerio (zebrafish) ]

    Gene ID: 554998, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pdia4provided by ZNC
    Official Full Name
    protein disulfide isomerase family A, member 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5493
    See related
    Ensembl:ENSDARG00000018491 AllianceGenome:ZFIN:ZDB-GENE-030131-5493
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cai; fj23a12; zgc:56014; zgc:77773; wu:fd20c07; wu:fj23a12; zgc:113965; zgc:136625
    Summary
    Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in cell surface and endoplasmic reticulum. Orthologous to human PDIA4 (protein disulfide isomerase family A member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pdia4 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (17334682..17341458)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (17190263..17197039)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 6 Neighboring gene polycystin 1 like 1, transient receptor potential channel interacting Neighboring gene si:dkey-117j14.6 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit Neighboring gene cullin 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Induction of endoplasmic reticulum stress markers in an acromegaly model. Elbialy A, et al. J Cell Biochem, 2022 Sep. PMID 35734917
    2. Effects of starch-coating of magnetite nanoparticles on cellular uptake, toxicity and gene expression profiles in adult zebrafish. Zheng M, et al. Sci Total Environ, 2018 May 1. PMID 29227944
    3. Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Zheng M, et al. Sci Rep, 2018 May 24. PMID 29795396, Free PMC Article
    4. A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver. Ramdas Nair A, et al. Genomics, 2022 Jan. PMID 34863900
    5. Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules. Grimholt U. BMC Evol Biol, 2018 Feb 23. PMID 29471808, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113965, MGC136625

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide-isomerase A4
    Names
    calcium binding protein, intestinal
    protein disulfide isomerase associated 4
    NP_956073.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199779.2 → NP_956073.2  protein disulfide-isomerase A4 precursor

      Status: VALIDATED

      Source sequence(s)
      BC117629, BX005392
      UniProtKB/TrEMBL
      A0A8M1PEJ6, Q1ECX9
      Related
      ENSDARP00000018458.5, ENSDART00000018868.7
      Conserved Domains (5) summary
      cd02995
      Location:523 → 628
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03068
      Location:283 → 389
      PDI_b_ERp72; PDIb family, ERp72 subfamily, first redox inactive TRX-like domain b; ERp72 exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting as ...
      cd03073
      Location:394 → 503
      PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
      TIGR01126
      Location:179 → 280
      pdi_dom; protein disulfide-isomerase domain
      TIGR01130
      Location:174 → 640
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      17334682..17341458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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