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    FIGN fidgetin, microtubule severing factor [ Homo sapiens (human) ]

    Gene ID: 55137, updated on 9-Dec-2024

    Summary

    Official Symbol
    FIGNprovided by HGNC
    Official Full Name
    fidgetin, microtubule severing factorprovided by HGNC
    Primary source
    HGNC:HGNC:13285
    See related
    Ensembl:ENSG00000182263 MIM:605295; AllianceGenome:HGNC:13285
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Predicted to be involved in cell division and microtubule cytoskeleton organization. Predicted to act upstream of or within locomotory behavior. Predicted to be located in nuclear matrix. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 1.1), fat (RPKM 1.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FIGN in Genome Data Viewer
    Location:
    2q24.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (163602611..163736008, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (164059859..164193293, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (164459121..164592518, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373727 Neighboring gene RNA, U6 small nuclear 627, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:164204489-164205088 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_55575 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_55577 Neighboring gene uncharacterized LOC107985829 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:164304809-164304985 Neighboring gene uncharacterized LOC105373728 Neighboring gene VISTA enhancer hs170 Neighboring gene NANOG hESC enhancer GRCh37_chr2:164478034-164478535 Neighboring gene Sharpr-MPRA regulatory region 10417 Neighboring gene uncharacterized LOC107985957 Neighboring gene VISTA enhancer hs640 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:164593125-164593641 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:164593642-164594157 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:164627636-164628835 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:164765722-164766240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:164766241-164766758 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:164809702-164810901 Neighboring gene VISTA enhancer hs421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16724 Neighboring gene Sharpr-MPRA regulatory region 13497 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:165027147-165027366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16725 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene 1 Neighboring gene cytochrome P450 family 2 subfamily C member 56, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients.
    EBI GWAS Catalog
    Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule severing ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321825.2NP_001308754.1  fidgetin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092684, AC093727
      Conserved Domains (1) summary
      COG0464
      Location:460735
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    2. NM_018086.4NP_060556.2  fidgetin isoform 1

      See identical proteins and their annotated locations for NP_060556.2

      Status: VALIDATED

      Source sequence(s)
      AC092684, AC093727, AK125324, BX649105
      Consensus CDS
      CCDS2221.2
      UniProtKB/Swiss-Prot
      B3KWM0, Q5HY92, Q9H6M5, Q9NVZ9
      Related
      ENSP00000333836.3, ENST00000333129.4
      Conserved Domains (1) summary
      COG0464
      Location:471746
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      163602611..163736008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444863.1XP_047300819.1  fidgetin isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      164059859..164193293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342736.1XP_054198711.1  fidgetin isoform X1