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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_023400.1 RefSeqGene
- Range
-
5001..22030
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_159
mRNA and Protein(s)
-
NM_000631.5 → NP_000622.2 neutrophil cytosol factor 4 isoform 1
See identical proteins and their annotated locations for NP_000622.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) lacks an internal coding segment compared to variant 2, which leads to a translation frameshift. The resulting isoform (1) has a distinct and shorter C-terminus, as compared to isoform 2.
- Source sequence(s)
-
BC002798, BU076892, BX355636
- Consensus CDS
-
CCDS13934.1
- UniProtKB/Swiss-Prot
- A8K4F9, O60808, Q15080, Q86U56, Q9BU98, Q9NP45
- UniProtKB/TrEMBL
- Q53FG4, Q6FGM9
- Related
- ENSP00000248899.6, ENST00000248899.11
- Conserved Domains (3) summary
-
- cd06399
Location:238 → 329
- PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...
- cd06882
Location:19 → 141
- PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
- cd11869
Location:174 → 227
- SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase
-
NM_013416.4 → NP_038202.2 neutrophil cytosol factor 4 isoform 2
See identical proteins and their annotated locations for NP_038202.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2). This isoform (2) lacks the PC (Phox and Cdc24p) motif, which may be important for the interaction with NCF2.
- Source sequence(s)
-
AK290924, BC002798
- Consensus CDS
-
CCDS13935.1
- UniProtKB/TrEMBL
-
A0A217FLJ2
- Related
- ENSP00000380334.4, ENST00000397147.7
- Conserved Domains (3) summary
-
- cd06882
Location:19 → 141
- PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
- cd11869
Location:174 → 227
- SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase
- cl02720
Location:238 → 258
- PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000022.11 Reference GRCh38.p14 Primary Assembly
- Range
-
36861006..36878015
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047441385.1 → XP_047297341.1 neutrophil cytosol factor 4 isoform X2
- UniProtKB/TrEMBL
- Q53FG4, Q6FGM9
-
XM_047441384.1 → XP_047297340.1 neutrophil cytosol factor 4 isoform X1
- UniProtKB/TrEMBL
- Q53FG4, Q6FGM9
Reference GRCh38.p14 ALT_REF_LOCI_1
Genomic
-
NT_187631.1 Reference GRCh38.p14 ALT_REF_LOCI_1
- Range
-
81800..101331
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060946.1 Alternate T2T-CHM13v2.0
- Range
-
37316866..37336974
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054325654.1 → XP_054181629.1 neutrophil cytosol factor 4 isoform X5
- UniProtKB/TrEMBL
-
A0A494BZS1
-
XM_054325656.1 → XP_054181631.1 neutrophil cytosol factor 4 isoform X6
-
XM_054325653.1 → XP_054181628.1 neutrophil cytosol factor 4 isoform X4
- UniProtKB/TrEMBL
-
A0A217FLJ2
-
XM_054325655.1 → XP_054181630.1 neutrophil cytosol factor 4 isoform X5
- UniProtKB/TrEMBL
-
A0A494BZS1
-
XM_054325651.1 → XP_054181626.1 neutrophil cytosol factor 4 isoform X3
- UniProtKB/TrEMBL
-
A0A217FLJ2
-
XM_054325652.1 → XP_054181627.1 neutrophil cytosol factor 4 isoform X1
- UniProtKB/TrEMBL
- Q53FG4, Q6FGM9