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    ADAM21 ADAM metallopeptidase domain 21 [ Homo sapiens (human) ]

    Gene ID: 8747, updated on 27-Nov-2024

    Summary

    Official Symbol
    ADAM21provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 21provided by HGNC
    Primary source
    HGNC:HGNC:200
    See related
    Ensembl:ENSG00000139985 MIM:603713; AllianceGenome:HGNC:200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADAM31; ADAM 21
    Summary
    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]
    Expression
    Biased expression in testis (RPKM 6.0) and brain (RPKM 0.2) See more
    Orthologs
    NEW
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    Genomic context

    See ADAM21 in Genome Data Viewer
    Location:
    14q24.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (70452174..70459905)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (64658196..64665929)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (70918891..70926622)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene SYNJ2BP-COX16 readthrough Neighboring gene RNA, U2 small nuclear 51, pseudogene Neighboring gene synaptojanin 2 binding protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:70866018-70866578 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:70883594-70884793 Neighboring gene uncharacterized LOC124903339 Neighboring gene MPRA-validated peak2189 silencer Neighboring gene ADAM metallopeptidase domain 20 pseudogene 1 Neighboring gene RNA, U6 small nuclear 659, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC125389

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metallopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in single fertilization TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 21
    Names
    ADAM metallopeptidase domain 21, preproprotein
    a disintegrin and metalloproteinase domain 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003813.4NP_003804.2  disintegrin and metalloproteinase domain-containing protein 21 preproprotein

      See identical proteins and their annotated locations for NP_003804.2

      Status: REVIEWED

      Source sequence(s)
      AA758110, AL357153, AL391223, DB035527
      Consensus CDS
      CCDS9804.1
      UniProtKB/Swiss-Prot
      O43507, Q2VPC6, Q32MR0, Q9UKJ8
      Related
      ENSP00000474385.1, ENST00000603540.2
      Conserved Domains (5) summary
      smart00608
      Location:491627
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:208396
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:415487
      Disintegrin; Disintegrin
      pfam01421
      Location:209398
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:50158
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      70452174..70459905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      64658196..64665929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)