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    MAN1A1 mannosidase alpha class 1A member 1 [ Homo sapiens (human) ]

    Gene ID: 4121, updated on 9-Dec-2024

    Summary

    Official Symbol
    MAN1A1provided by HGNC
    Official Full Name
    mannosidase alpha class 1A member 1provided by HGNC
    Primary source
    HGNC:HGNC:6821
    See related
    Ensembl:ENSG00000111885 MIM:604344; AllianceGenome:HGNC:6821
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAN9; HUMM3; HUMM9
    Summary
    This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in fat (RPKM 62.7), liver (RPKM 46.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MAN1A1 in Genome Data Viewer
    Location:
    6q22.31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (119177205..119350605, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (120363405..120543535, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (119498370..119670926, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance 9 homologous recombination repair factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17507 Neighboring gene uncharacterized LOC124901389 Neighboring gene family with sequence similarity 184 member A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:119361669-119362560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17508 Neighboring gene MPRA-validated peak6067 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr6:119411357-119411858 Neighboring gene Sharpr-MPRA regulatory region 12550 Neighboring gene microRNA 548b Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17509 Neighboring gene ribosomal protein L13a pseudogene 15 Neighboring gene Sharpr-MPRA regulatory region 13895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17512 Neighboring gene RNA, U6 small nuclear 194, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25018 Neighboring gene uncharacterized LOC107986525 Neighboring gene uncharacterized LOC285762 Neighboring gene uncharacterized LOC105377975 Neighboring gene NANOG hESC enhancer GRCh37_chr6:119943697-119944198 Neighboring gene uncharacterized LOC105377972

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of mannosidase, alpha, class 1A, member 1 (MAN1A1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
    env HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex PubMed
    Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
    Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20935

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mannosidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Golgi apparatus mannose trimming TAS
    Traceable Author Statement
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mannose trimming involved in glycoprotein ERAD pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein targeting to ER IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
    Names
    Man9-mannosidase
    alpha-1,2-mannosidase IA
    man(9)-alpha-mannosidase
    processing alpha-1,2-mannosidase IA
    NP_005898.2
    XP_005267043.1
    XP_011534135.1
    XP_047274731.1
    XP_054211415.1
    XP_054211416.1
    XP_054211417.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005907.4NP_005898.2  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

      See identical proteins and their annotated locations for NP_005898.2

      Status: REVIEWED

      Source sequence(s)
      AK025599, AL022722, BQ008013
      Consensus CDS
      CCDS5122.1
      UniProtKB/Swiss-Prot
      E7EU32, P33908, Q6P052, Q9NU44, Q9UJI3
      Related
      ENSP00000357453.3, ENST00000368468.4
      Conserved Domains (1) summary
      pfam01532
      Location:202640
      Glyco_hydro_47; Glycosyl hydrolase family 47

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      119177205..119350605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266986.5XP_005267043.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1

      Conserved Domains (1) summary
      pfam01532
      Location:285723
      Glyco_hydro_47; Glycosyl hydrolase family 47
    2. XM_011535833.3XP_011534135.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X2

      Conserved Domains (1) summary
      pfam01532
      Location:13451
      Glyco_hydro_47; Glycosyl hydrolase family 47
    3. XM_047418775.1XP_047274731.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      120363405..120543535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355440.1XP_054211415.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1

    2. XM_054355441.1XP_054211416.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X2

    3. XM_054355442.1XP_054211417.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X3