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    Wdr86 WD repeat domain 86 [ Mus musculus (house mouse) ]

    Gene ID: 269633, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Wdr86provided by MGI
    Official Full Name
    WD repeat domain 86provided by MGI
    Primary source
    MGI:MGI:1915466
    See related
    Ensembl:ENSMUSG00000055235 AllianceGenome:MGI:1915466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810046M22Rik
    Summary
    Is expressed in cerebral cortex ventricular layer; choroid plexus; meninges; and testis. Orthologous to human WDR86 (WD repeat domain 86). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.1), placenta adult (RPKM 3.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wdr86 in Genome Data Viewer
    Location:
    5 A3; 5 11.93 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24901898..24935696, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24696900..24730698, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor 2 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Neighboring gene glycerol-3-phosphate dehydrogenase 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_12645 Neighboring gene STARR-positive B cell enhancer mm9_chr5:24180078-24180378 Neighboring gene STARR-positive B cell enhancer ABC_E1298 Neighboring gene STARR-positive B cell enhancer ABC_E11722 Neighboring gene negative regulator of ubiquitin-like proteins 1 Neighboring gene VISTA enhancer mm394 Neighboring gene predicted gene, 42231 Neighboring gene STARR-seq mESC enhancer starr_12647 Neighboring gene predicted gene, 33591 Neighboring gene crystallin, gamma N

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607
    2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 86

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081441.1 → NP_001074910.1  WD repeat-containing protein 86

      See identical proteins and their annotated locations for NP_001074910.1

      Status: VALIDATED

      Source sequence(s)
      BC059069, BY712199, CA328147, CN527054, CN528185
      Consensus CDS
      CCDS39031.1
      UniProtKB/TrEMBL
      D3Z757
      Related
      ENSMUSP00000064785.6, ENSMUST00000068693.12
      Conserved Domains (4) summary
      smart00320
      Location:304 → 341
      WD40; WD40 repeats
      COG2319
      Location:24 → 345
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:8 → 301
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61 → 95
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      24901898..24935696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535720.5 → XP_006535783.1  WD repeat-containing protein 86 isoform X3

      Conserved Domains (2) summary
      cd00200
      Location:8 → 284
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61 → 95
      7WD40; WD40 repeat [structural motif]

    2. XM_006535718.4 → XP_006535781.1  WD repeat-containing protein 86 isoform X1

      Conserved Domains (3) summary
      smart00320
      Location:334 → 371
      WD40; WD40 repeats
      cd00200
      Location:8 → 289
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61 → 95
      7WD40; WD40 repeat [structural motif]

    3. XM_006535719.4 → XP_006535782.1  WD repeat-containing protein 86 isoform X2

      Conserved Domains (2) summary
      cd00200
      Location:11 → 327
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:17 → 51
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_001784702.2 RNA Sequence

    2. XR_003955653.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026621.1: Suppressed sequence

      Description
      NM_026621.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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