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    byr2 MAP kinase kinase kinase Byr2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540612, updated on 14-Nov-2024

    Summary

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    Official Symbol
    byr2
    Official Full Name
    MAP kinase kinase kinase Byr2
    Primary source
    PomBase:SPBC1D7.05
    Locus tag
    SPOM_SPBC1D7.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPBC2F12.01; ste8
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    Genomic context

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    See byr2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1740048..1742344, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitochondrial 54S ribosomal protein uL5m Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA-binding protein Mlo3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution structure of the Ras binding domain of the protein kinase Byr2 from Schizosaccharomyces pombe. Gronwald W, et al. Structure, 2001 Nov. PMID 11709167
    2. Functional conservation between Schizosaccharomyces pombe ste8 and Saccharomyces cerevisiae STE11 protein kinases in yeast signal transduction. Styrkársdóttir U, et al. Mol Gen Genet, 1992 Oct. PMID 1435723
    3. The Byr2 kinase translocates to the plasma membrane in a Ras1-dependent manner. Bauman P, et al. Biochem Biophys Res Commun, 1998 Mar 17. PMID 9514947
    4. Oligomerization-dependent association of the SAM domains from Schizosaccharomyces pombe Byr2 and Ste4. Ramachander R, et al. J Biol Chem, 2002 Oct 18. PMID 12171939
    5. SAM domains can utilize similar surfaces for the formation of polymers and closed oligomers. Ramachander R, et al. J Mol Biol, 2004 Oct 1. PMID 15364564

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutational analyses of the interacting domains of Schizosaccharomyces pombe Byr2 with 14-3-3s.
      Title: Mutational analyses of the interacting domains of Schizosaccharomyces pombe Byr2 with 14-3-3s.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables MAP kinase kinase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pheromone response MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAP kinase kinase kinase Byr2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1740048..1742344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021611.4 → NP_595714.2  MAP kinase kinase kinase Byr2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595714.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P28829, Q7LGJ0
      Conserved Domains (2) summary
      pfam00069
      Location:394 → 658
      Pkinase; Protein kinase domain
      cl21453
      Location:393 → 658
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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