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    USP32 ubiquitin specific peptidase 32 [ Homo sapiens (human) ]

    Gene ID: 84669, updated on 3-Dec-2024

    Summary

    Official Symbol
    USP32provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 32provided by HGNC
    Primary source
    HGNC:HGNC:19143
    See related
    Ensembl:ENSG00000170832 MIM:607740; AllianceGenome:HGNC:19143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USP10; NY-REN-60
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in positive regulation of TORC1 signaling. Located in cytosol. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 36.8), brain (RPKM 14.5) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See USP32 in Genome Data Viewer
    Location:
    17q23.1-q23.2
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (60177327..60422416, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (61046275..61291441, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (58254688..58469494, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:58216417-58216950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:58217485-58218018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:58218675-58219231 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:58219938-58220447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:58232505-58233005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:58235149-58235978 Neighboring gene Sharpr-MPRA regulatory region 8996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12527 Neighboring gene carbonic anhydrase 4 Neighboring gene family with sequence similarity 106 member D, pseudogene Neighboring gene small Cajal body-specific RNA 20 Neighboring gene ribosomal protein L32 pseudogene 32 Neighboring gene septin 7 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8787 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:58402707-58402860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:58405017-58405863 Neighboring gene H3 histone pseudogene 42 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:58462897-58463708 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:58469209-58470050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12530 Neighboring gene uncharacterized LOC105371850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8791 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8793 Neighboring gene ribosomal protein L12 pseudogene 38 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 42 Neighboring gene CHD1 helical C-terminal domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 32
    Names
    deubiquitinating enzyme 32
    renal carcinoma antigen NY-REN-60
    ubiquitin specific protease 32
    ubiquitin thioesterase 32
    ubiquitin thiolesterase 32
    ubiquitin-specific-processing protease 32
    NP_115971.2
    XP_011523673.1
    XP_011523674.1
    XP_011523675.1
    XP_011523676.1
    XP_011523677.1
    XP_011523678.1
    XP_011523680.1
    XP_011523681.1
    XP_016880722.1
    XP_047292899.1
    XP_047292900.1
    XP_047292901.1
    XP_054173541.1
    XP_054173542.1
    XP_054173543.1
    XP_054173544.1
    XP_054173545.1
    XP_054173546.1
    XP_054173547.1
    XP_054173548.1
    XP_054173549.1
    XP_054173550.1
    XP_054173551.1
    XP_054173552.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032582.4NP_115971.2  ubiquitin carboxyl-terminal hydrolase 32

      See identical proteins and their annotated locations for NP_115971.2

      Status: VALIDATED

      Source sequence(s)
      AC025048, AF533230, AL834444, BI459907
      Consensus CDS
      CCDS32697.1
      UniProtKB/Swiss-Prot
      Q7Z5T3, Q8NFA0, Q9BX85, Q9Y591
      Related
      ENSP00000300896.3, ENST00000300896.9
      Conserved Domains (6) summary
      COG5560
      Location:5181316
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:237293
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12251565
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:519586
      DUSP; DUSP domain
      pfam13499
      Location:236293
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:623710
      Ubiquitin_3; Ubiquitin-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      60177327..60422416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525372.2XP_011523674.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X2

      Conserved Domains (6) summary
      COG5560
      Location:5341332
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:253309
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12411581
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:535602
      DUSP; DUSP domain
      pfam13499
      Location:252309
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:639726
      Ubiquitin_3; Ubiquitin-like domain
    2. XM_011525371.2XP_011523673.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X1

      Conserved Domains (6) summary
      COG5560
      Location:5341346
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:253309
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12551595
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:535602
      DUSP; DUSP domain
      pfam13499
      Location:252309
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:653740
      Ubiquitin_3; Ubiquitin-like domain
    3. XM_011525376.2XP_011523678.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X6

      Conserved Domains (6) summary
      COG5560
      Location:5151313
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:234290
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12221562
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:516583
      DUSP; DUSP domain
      pfam13499
      Location:233290
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:620707
      Ubiquitin_3; Ubiquitin-like domain
    4. XM_011525374.2XP_011523676.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X4

      Conserved Domains (6) summary
      COG5560
      Location:5151327
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:234290
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12361576
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:516583
      DUSP; DUSP domain
      pfam13499
      Location:233290
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:634721
      Ubiquitin_3; Ubiquitin-like domain
    5. XM_011525373.2XP_011523675.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X3

      Conserved Domains (6) summary
      COG5560
      Location:5181330
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:237293
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12391579
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:519586
      DUSP; DUSP domain
      pfam13499
      Location:236293
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:637724
      Ubiquitin_3; Ubiquitin-like domain
    6. XM_011525375.2XP_011523677.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X5

      Conserved Domains (6) summary
      COG5560
      Location:5081320
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:227283
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12291569
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:509576
      DUSP; DUSP domain
      pfam13499
      Location:226283
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:627714
      Ubiquitin_3; Ubiquitin-like domain
    7. XM_047436943.1XP_047292899.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X7

    8. XM_047436944.1XP_047292900.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X10

      UniProtKB/TrEMBL
      K7EQL6
    9. XM_017025233.2XP_016880722.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X9

      UniProtKB/TrEMBL
      K7EQL6
    10. XM_011525378.2XP_011523680.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X8

      UniProtKB/TrEMBL
      K7EQL6
      Conserved Domains (6) summary
      COG5560
      Location:4721284
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:191247
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:11931533
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:473540
      DUSP; DUSP domain
      pfam13499
      Location:190247
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:591678
      Ubiquitin_3; Ubiquitin-like domain
    11. XM_011525379.4XP_011523681.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X11

      UniProtKB/TrEMBL
      K7EQL6
      Conserved Domains (4) summary
      COG5560
      Location:2271039
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cl02553
      Location:9481288
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:228295
      DUSP; DUSP domain
      pfam14836
      Location:346433
      Ubiquitin_3; Ubiquitin-like domain
    12. XM_047436945.1XP_047292901.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X12

      UniProtKB/TrEMBL
      K7EQL6
      Related
      ENSP00000467885.1, ENST00000592339.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      61046275..61291441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317567.1XP_054173542.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X2

    2. XM_054317566.1XP_054173541.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X1

    3. XM_054317571.1XP_054173546.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X6

    4. XM_054317569.1XP_054173544.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X4

    5. XM_054317568.1XP_054173543.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X3

    6. XM_054317570.1XP_054173545.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X5

    7. XM_054317572.1XP_054173547.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X7

    8. XM_054317575.1XP_054173550.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X10

      UniProtKB/TrEMBL
      K7EQL6
    9. XM_054317574.1XP_054173549.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X9

      UniProtKB/TrEMBL
      K7EQL6
    10. XM_054317573.1XP_054173548.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X8

      UniProtKB/TrEMBL
      K7EQL6
    11. XM_054317576.1XP_054173551.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X11

      UniProtKB/TrEMBL
      K7EQL6
    12. XM_054317577.1XP_054173552.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X12

      UniProtKB/TrEMBL
      K7EQL6