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    BATF2 basic leucine zipper ATF-like transcription factor 2 [ Homo sapiens (human) ]

    Gene ID: 116071, updated on 27-Nov-2024

    Summary

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    Official Symbol
    BATF2provided by HGNC
    Official Full Name
    basic leucine zipper ATF-like transcription factor 2provided by HGNC
    Primary source
    HGNC:HGNC:25163
    See related
    Ensembl:ENSG00000168062 MIM:614983; AllianceGenome:HGNC:25163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SARI
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to protozoan; myeloid dendritic cell differentiation; and regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen (RPKM 7.0), appendix (RPKM 4.9) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BATF2 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64987945..64996971, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64981187..64990214, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64755417..64764443, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit B'beta Neighboring gene glycoprotein hormone subunit alpha 2 Neighboring gene membrane anchored junction protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64757136-64757663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64763842-64764342 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3163 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:64773912-64775111 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3504 Neighboring gene ARL2-SNX15 readthrough (NMD candidate) Neighboring gene microRNA 6879 Neighboring gene ARF like GTPase 2 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Decreased SARI expression predicts poor prognosis of Chinese patients with non-small cell lung cancer. Zhou RJ, et al. Int J Clin Exp Pathol, 2013. PMID 24133583, Free PMC Article
    2. BATF2 in human colorectal cancer. Liu Z, et al. Aging (Albany NY), 2015 May. PMID 26022579, Free PMC Article
    3. The tumor-suppressive role of BATF2 in esophageal squamous cell carcinoma. Han T, et al. Oncol Rep, 2015 Sep. PMID 26135942
    4. Expression and mechanism of action of the SARI tumor suppressor in prostate cancer. Chen Q, et al. Int J Clin Exp Pathol, 2015. PMID 26339361, Free PMC Article
    5. SARI, a novel target gene of glucocorticoid receptor, plays an important role in dexamethasone-mediated killing of B lymphoma cells. Huang Y, et al. Cancer Lett, 2016 Apr 1. PMID 26808579

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal miR-361-3p promotes the viability of breast cancer cells by targeting ETV7 and BATF2 to upregulate the PAI-1/ERK pathway.
      Title: Exosomal miR-361-3p promotes the viability of breast cancer cells by targeting ETV7 and BATF2 to upregulate the PAI-1/ERK pathway.
    2. BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer.
      Title: BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer.
    3. Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1.
      Title: Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1.
    4. Loss of the Immunomodulatory Transcription Factor BATF2 in Humans Is Associated with a Neurological Phenotype.
      Title: Loss of the Immunomodulatory Transcription Factor BATF2 in Humans Is Associated with a Neurological Phenotype.
    5. m6A modification-mediated BATF2 suppresses metastasis and angiogenesis of tongue squamous cell carcinoma through inhibiting VEGFA.
      Title: m6A modification-mediated BATF2 suppresses metastasis and angiogenesis of tongue squamous cell carcinoma through inhibiting VEGFA.
    6. SARI inhibits growth and reduces survival of oral squamous cell carcinomas (OSCC) by inducing endoplasmic reticulum stress.
      Title: SARI inhibits growth and reduces survival of oral squamous cell carcinomas (OSCC) by inducing endoplasmic reticulum stress.
    7. Expression and clinical implications of basic leucine zipper ATF-like transcription factor 2 in breast cancer.
      Title: Expression and clinical implications of basic leucine zipper ATF-like transcription factor 2 in breast cancer.
    8. BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells.
      Title: BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells.
    9. BATF2 expression as a novel marker for invasive phenotype in malignant melanoma.
      Title: BATF2 expression as a novel marker for invasive phenotype in malignant melanoma.
    10. miRNA-765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells.
      Title: miRNA-765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC20410

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to protozoan ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in integrated stress response signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in myeloid dendritic cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    basic leucine zipper transcriptional factor ATF-like 2
    Names
    B-ATF-2
    basic leucine zipper transcription factor, ATF-like 2
    suppressor of AP-1 regulated by IFN

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300807.2 → NP_001287736.1  basic leucine zipper transcriptional factor ATF-like 2 isoform 2

      See identical proteins and their annotated locations for NP_001287736.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon in place of the first two exons compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK300917, BP206576, HM134154
      Consensus CDS
      CCDS76429.1
      UniProtKB/TrEMBL
      B4DV37
      Related
      ENSP00000434915.1, ENST00000527716.1
      Conserved Domains (1) summary
      cl21462
      Location:23 → 50
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    2. NM_001300808.2 → NP_001287737.1  basic leucine zipper transcriptional factor ATF-like 2 isoform 3

      See identical proteins and their annotated locations for NP_001287737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate exon in place of the first two exons compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK092453, BP206576, HM134154
      Consensus CDS
      CCDS73317.1
      UniProtKB/Swiss-Prot
      Q8N1L9
      Related
      ENSP00000398911.2, ENST00000435842.2

    3. NM_138456.4 → NP_612465.3  basic leucine zipper transcriptional factor ATF-like 2 isoform 1

      See identical proteins and their annotated locations for NP_612465.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK096702, BC012330
      Consensus CDS
      CCDS8087.1
      UniProtKB/Swiss-Prot
      D9IC56, Q8N1L9, Q8NAF4, Q8NAL8, Q96EH4
      Related
      ENSP00000301887.4, ENST00000301887.9
      Conserved Domains (1) summary
      cd14701
      Location:17 → 74
      bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      64987945..64996971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      64981187..64990214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N1L9.1 GenPept UniProtKB/Swiss-Prot:Q8N1L9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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